Effects of long-term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle.
I Kodama, R Suzuki, K Kamiya, H Iwata… - British journal of …, 1992 - ncbi.nlm.nih.gov
The effects of long-term administration of oral amiodarone on transmembrane action
potential and contraction of ventricular muscle were investigated in rabbits. 2. ECGs of …
potential and contraction of ventricular muscle were investigated in rabbits. 2. ECGs of …
Chronic in vivo and in vitro effects of amiodarone on guinea pig hearts.
EA Sosunov, EP Anyukhovsky… - The Journal of …, 1996 - jpet.aspetjournals.org
To study the electrophysiologic effects of chronically administered amiodarone and its
interaction with an I (Kr) blocker, amiodarone was injected ip daily for 7 days into male …
interaction with an I (Kr) blocker, amiodarone was injected ip daily for 7 days into male …
Does acute exposure to amiodarone prolong cardiac action potential duration?
M Aomine - General Pharmacology: The Vascular System, 1988 - Elsevier
1. The acute effects of a potent antiarrhythmic agent, amiodarone (AM), were studied in
isolated guinea pig ventricular muscle. Transmembrane action potentials were recorded by …
isolated guinea pig ventricular muscle. Transmembrane action potentials were recorded by …
Acute and chronic effects of amiodarone on mammalian ventricular cells
I Kodama, K Kamiya, H Honjo, J Toyama - Japanese heart journal, 1996 - jstage.jst.go.jp
This article reviews experimental studies on the electrophysiological effects of amiodarone
on mammalian hearts. Acute application of amiodarone (0.1-10ƒÊM) to papillary muscles or …
on mammalian hearts. Acute application of amiodarone (0.1-10ƒÊM) to papillary muscles or …
Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo.
KP Anderson, R Walker, T Dustman, RL Lux… - Circulation, 1989 - Am Heart Assoc
The electrophysiologic effects of amiodarone were examined in 13 dogs that received 30 g
amiodarone orally during 3 weeks and compared with 13 control dogs that did not receive …
amiodarone orally during 3 weeks and compared with 13 control dogs that did not receive …
Electrophysiologic effects of amiodarone: experimental and clinical observation relative to serum and tissue drug concentrations
N Ikeda, K Nademanee, R Kannan, BN Singh - American heart journal, 1984 - Elsevier
Oral amiodarone is a potent antiarrhythmic agent with a slow onset of action. Its
electrophysiologic properties following chronic administration are well known, but its acute …
electrophysiologic properties following chronic administration are well known, but its acute …
Electrophysiological effects of amiodarone on isolated rabbit heart muscles
M Kadoya, T Konishi, T Tamamura… - Journal of …, 1985 - journals.lww.com
We studied the electrophysiological effects of amiodarone on isolated rabbit heart muscles
by conventional microelectrode techniques. It significantly suppressed not only sinus node …
by conventional microelectrode techniques. It significantly suppressed not only sinus node …
Resting, and rate-dependent depression of Vmax of guinea-pig ventricular action potentials by amiodarone and desethylamiodarone.
RT Pallandi, TJ Campbell - British journal of pharmacology, 1987 - ncbi.nlm.nih.gov
Abstract 1 The cellular electrophysiological effects of amiodarone and its metabolite
desethylamiodarone (DEA) were studied in guinea-pig ventricular myocardium by use of …
desethylamiodarone (DEA) were studied in guinea-pig ventricular myocardium by use of …
Electropharmacology of amiodarone: absence of relationship to serum, myocardial, and cardiac sarcolemmal membrane drug concentrations
N Venkatesh, P Somani, M Bersohn, R Phair… - American Heart …, 1986 - Elsevier
Plasma concentrations are often of major consideration in the evaluation of therapeutic
efficacy of cardiovascular drugs. This approach is based on the assumptions that the …
efficacy of cardiovascular drugs. This approach is based on the assumptions that the …
Inhibition by amiodarone of slow response action potentials and contraction in guinea pig ventricular muscle.
M Aomine - General Pharmacology, 1988 - europepmc.org
1. Effects of an antiarrhythmic agent, amiodarone (AM), on slow response action potentials
and contraction of guinea pig ventricular muscle were examined. 2. AM (4.4 x 10 (-5) M, 1.1 …
and contraction of guinea pig ventricular muscle were examined. 2. AM (4.4 x 10 (-5) M, 1.1 …