Arginine and proline derive from the metabolism of Δ1-pyrolline-5-carboxylate, a product of
intestinal glutamic acid metabolism. We studied the extent of glutamate, arginine, and …

The many enzyme reactions involved in the interconversion of glutamate, ornithine, proline
and arginine are interrelated to one another by the metabolite pyrroline-5-carboxylate. This …

There is considerable controversy recently in identifying dietary precursors for arginine
synthesis. We have previously shown in human neonates and piglets that proline is the sole …

This study examined plasma proline concentration flux, oxidation, and endogenous
biosynthesis in five healthy young men given three isocaloric, isonitrogenous diets for 1 wk …

To explore the response of whole-body arginine metabolism to a change in arginine intake,
plasma arginine kinetics were investigated in eight healthy adult men who received an l …

A quantitative exploration of the regulation of plasma proline concentration, proline
oxidation, and proline endogenous biosynthesis was undertaken utilizing a 360-minute …

The in vivo synthesis of arginine from glutamate in mammals requires seven enzymes to
cooperate. Pyrroline-5-carboxylate synthase (PCS) is the first enzyme required. In order to …

Background: We previously confirmed in humans the existence of a pathway of glutamine
into citrulline and arginine, which is preferentially stimulated by luminally provided …

Recent studies have documented transfer of labeled nitrogen from [2-15N] glutamine to
citrulline and arginine in fasting human adults. Conversely, in neonates and piglets we have …

A method for measuring 5-L-oxoproline in urine, which involves isolation by short-column
chromatography, acid hydrolysis to glutamic acid and enzymic assay of glutamic acid, was …