Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition

V Chandran, EJ Stollar, K Lindorff-Larsen… - Journal of molecular …, 2006 - Elsevier
Calcium-dependent protein kinases (CDPKs) are a class of calcium-binding sensory
proteins that are found in plants and certain protozoa, including the causative agent of …

Evidence for differing roles for each lobe of the calmodulin-like domain in a calcium-dependent protein kinase

J Christodoulou, A Malmendal, JF Harper… - Journal of Biological …, 2004 - ASBMB
Calcium-dependent protein kinases (CDPKs) are structurally unique Ser/Thr kinases found
in plants and certain protozoa. They are distinguished by a calmodulin-like regulatory …

Intramolecular Activation of a Ca2+-Dependent Protein Kinase Is Disrupted by Insertions in the Tether That Connects the Calmodulin-like Domain to the Kinase

V Vitart, J Christodoulou, JF Huang, WJ Chazin… - Biochemistry, 2000 - ACS Publications
Ca2+-dependent protein kinases (CDPK) have a calmodulin-like domain (CaM-LD) tethered
to the C-terminal end of the kinase. Activation is proposed to involve intramolecular binding …

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

AK Wernimont, JD Artz, P Finerty Jr, YH Lin… - Nature structural & …, 2010 - nature.com
Calcium-dependent protein kinases (CDPKs) have pivotal roles in the calcium-signaling
pathway in plants, ciliates and apicomplexan parasites and comprise a calmodulin …

Activation of a Ca2+-Dependent Protein Kinase Involves Intramolecular Binding of a Calmodulin-like Regulatory Domain

JF Huang, L Teyton, JF Harper - Biochemistry, 1996 - ACS Publications
Ca2+-dependent protein kinases (CDPKs) are regulated by a C-terminal calmodulin-like
domain (CaM-LD). The CaM-LD is connected to the kinase by a short junction sequence …

Unexpected structure of the Ca2+-regulatory region from soybean calcium-dependent protein kinase-α

AM Weljie, HJ Vogel - Journal of Biological Chemistry, 2004 - ASBMB
Calcium-dependent protein kinases (CDPKs) are an extensive class of multidomain Ca 2+-
regulated enzymes from plants and protozoa. In vivo the so-called calmodulin-like domain …

Calcium/calmodulin-dependent protein kinase kinase: identification of regulatory domains

H Tokumitsu, GA Wayman, M Muramatsu… - Biochemistry, 1997 - ACS Publications
We recently cloned a calmodulin-dependent protein kinase kinase (CaM-KK) which
phosphorylates and activates CaM-KI and CaM-KIV [Tokumitsu, H., Enslen, H., and …

Structures of parasitic CDPK domains point to a common mechanism of activation

AK Wernimont, M Amani, W Qiu… - Proteins: Structure …, 2011 - Wiley Online Library
We recently determined the first structures of inactivated and calcium‐activated calcium‐
dependent protein kinases (CDPKs) from Apicomplexa. Calcium binding triggered a large …

Domain analysis of a groundnut calcium-dependent protein kinase: nuclear localization sequence in the junction domain is coupled with nonconsensus calcium …

A Raichaudhuri, R Bhattacharyya, S Chaudhuri… - Journal of Biological …, 2006 - ASBMB
The signature of calcium-dependent protein kinases (CDPKs) is a C-terminal calmodulin-
like domain (CaMLD) with four consensus calcium-binding sites. A junction domain (JD) …

Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I

T Yuan, AV Gomes, JA Barnes, HN Hunter… - Archives of biochemistry …, 2004 - Elsevier
Structural studies of the calmodulin-dependent protein kinase I have shown how the
calmodulin-binding domain and autoinhibitory domain interact with the active sites of the …