Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy
Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can induce tumor
regression in up to 50% or more of patients with unresectable metastatic melanoma …
regression in up to 50% or more of patients with unresectable metastatic melanoma …
Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor …
JA Hernandez-Chacon, Y Li, RC Wu… - Journal of …, 2011 - journals.lww.com
Adoptive T-cell therapy (ACT) using expanded tumor-infiltrating lymphocytes (TIL) with high-
dose interleukin-2 is a promising form of immunotherapy for stage IV melanoma having …
dose interleukin-2 is a promising form of immunotherapy for stage IV melanoma having …
Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
JA Chacon, AA Sarnaik, JQ Chen, C Creasy… - Clinical Cancer …, 2015 - AACR
Purpose: Cultured tumor fragments from melanoma metastases have been used for years as
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …
MART-1–specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic …
Y Li, S Liu, J Hernandez, L Vence, P Hwu… - The journal of …, 2010 - journals.aai.org
We determined how CD8+ melanoma tumor–infiltrating lymphocytes (TILs) isolated from two
distinct phases of expansion in preparation for adoptive T cell therapy respond to melanoma …
distinct phases of expansion in preparation for adoptive T cell therapy respond to melanoma …
Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma
Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) is a
therapy for metastatic melanoma with response rates of up to 50%. However, the generation …
therapy for metastatic melanoma with response rates of up to 50%. However, the generation …
SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4+ T Cells into CD4+FoxP3+ T Regulatory Cells by Production of IFN-γ
S Madireddi, RH Schabowsky, AK Srivastava… - 2012 - journals.plos.org
Tumors convert conventional CD4+ T cells into induced CD4+ CD25+ FoxP3+ T regulatory
(iTreg) cells that serve as an effective means of immune evasion. Therefore, the blockade of …
(iTreg) cells that serve as an effective means of immune evasion. Therefore, the blockade of …
Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma
E Huarte, J Fisher, MJ Turk, D Mellinger, C Foster… - Cancer letters, 2009 - Elsevier
Although T Central Memory cells have been described as the most effective T-cell subtype
against tumor growth, little is known about the requirements needed for their optimal ex vivo …
against tumor growth, little is known about the requirements needed for their optimal ex vivo …
4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2nd Generation Chimeric Antigen Receptor-Modified T Cells
Q Dai, P Han, X Qi, F Li, M Li, L Fan, H Zhang… - Frontiers in …, 2020 - frontiersin.org
While chimeric antigen receptor-modified T (CAR-T) cells have shown great success for the
treatment of B cell leukemia, their efficacy appears to be compromised in B cell derived …
treatment of B cell leukemia, their efficacy appears to be compromised in B cell derived …
CD8+ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs
Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves
antitumor immune responses in preclinical studies, clinical success has been limited by on …
antitumor immune responses in preclinical studies, clinical success has been limited by on …
[HTML][HTML] 4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells
Background Co-stimulatory signals regulate the expansion, persistence, and function of
chimeric antigen receptor (CAR) T cells. Most studies have focused on the co-stimulatory …
chimeric antigen receptor (CAR) T cells. Most studies have focused on the co-stimulatory …