The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular
synapse development and for the formation and plasticity of synapses within the CNS …

Despite its key role in Alzheimer pathogenesis, the physiological function (s) of the amyloid
precursor protein (APP) and its proteolytic fragments are still poorly understood. Previously …

Biochemical and genetic studies place the amyloid precursor protein (APP) at the center
stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead …

It is well established that the proteolytic processing of the β-amyloid precursor protein (APP)
generates β-amyloid (Aβ), which plays a central role in the pathogenesis of Alzheimer's …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

The amyloid precursor protein (APP), whose mutations cause familial Alzheimer's disease,
interacts with the synaptic release machinery, suggesting a role in neurotransmission. Here …

Abstract APP, APLP1, and APLP2 form a family of mammalian membrane proteins with
unknown function. APP, however, plays a key role in the molecular pathology of Alzheimer's …

Alzheimer9s disease (AD) is histopathologically characterized by Aβ plaques and the
accumulation of hyperphosphorylated Tau species, the latter also constituting key hallmarks …

A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD)
pathogenesis has been well established. However, the physiological function of APP …

The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer's
disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is …