Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance

LD Hernández‐Ortega… - Journal of …, 2012 - Wiley Online Library
Abstract Background and Aim Development of hepatic cirrhosis involves oxidative stress,
inflammation, hepatic stellate cells (HSC) s activation and fibrosis. On the other hand …

Effect of Quercetin on the fructose-activated human hepatic stellate cells, LX-2, an in-vitro study

E Shakerian, R Afarin, R Akbari… - Molecular Biology …, 2022 - Springer
Background Hepatic fibrosis is one of the main reasons for mortality in the world. Hepatic
stellate cells (HSCs) activate during chronic liver injury, express more Transforming growth …

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

L Wu, Q Zhang, W Mo, J Feng, S Li, J Li, T Liu, S Xu… - Scientific reports, 2017 - nature.com
The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a
characteristic response to acute or chronic liver injury. Mice were randomized to bile duct …

Antiproliferative mechanisms of quercetin in rat activated hepatic stellate cells

L Wu, I Lu, CF Chung, HY Wu, YT Liu - Food & Function, 2011 - pubs.rsc.org
Quercetin, rich in fruits and vegetables, has been used as a nutritional supplement because
of its anti-inflammatory and antioxidative properties. Its positive effects on anti-hepatic …

The flavonoid quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice

X Li, Q Jin, Q Yao, B Xu, L Li, S Zhang… - Frontiers in …, 2018 - frontiersin.org
At present, there are no effective antifibrotic drugs for patients with chronic liver disease;
hence, the development of antifibrotic therapies is urgently needed. Here, we performed an …

Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways

X Li, Q Jin, Q Yao, B Xu, Z Li, C Tu - Toxicology letters, 2016 - Elsevier
This study aimed to investigate the effects of quercetin on liver fibrogenesis in mice and to
elucidate the underlying molecular mechanisms. Mice were administered with carbon …

Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

R Wang, H Zhang, Y Wang, F Song, Y Yuan - International …, 2017 - Elsevier
Quercetin, a natural flavonoid, has been used as a nutritional supplement for its anti-
inflammatory and antioxidative properties. Quercetin was reported to exhibit a wide range of …

The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta‐analysis

X Guo, Y Li, W Wang, L Wang, S Hu… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Quercetin (3, 3′, 4′, 5, 7‐pentahydroxyflavone), a flavonoid, is widely found in
fruits and vegetables and exerts broad‐spectrum pharmacological effects in the liver. Many …

The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats

ES Lee, HE Lee, JY Shin, S Yoon… - Journal of pharmacy …, 2003 - Wiley Online Library
Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a
wide range of pharmacological properties. In this study, we investigated the protective effect …

Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways

YA Salama, HM Hassan, AM El-Gayar… - Life Sciences, 2024 - Elsevier
Liver fibrosis involves several signalling pathways working in concert regulating the
deposition of extracellular matrix. In this study, we evaluated the effect of quercetin and …