Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans

L Wang, MJ Nissi, F Toth, CP Johnson… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To use quantitative susceptibility mapping (QSM) to investigate changes in
cartilage canals in the distal femur of juvenile goats after their surgical transection. Methods …

In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise

F Tóth, FH David, E LaFond, L Wang… - Journal of …, 2017 - Wiley Online Library
In vivo visualization of subclinical osteochondrosis (OC) lesions, characterized by necrosis
of epiphyseal growth cartilage, is necessary to clarify the pathogenesis of this disease …

Novel application of magnetic resonance imaging demonstrates characteristic differences in vasculature at predilection sites of osteochondritis dissecans

F Toth, MJ Nissi, JM Ellermann… - … American journal of …, 2015 - journals.sagepub.com
Background: Understanding the pathogenesis of osteochondrosis/osteochondritis dissecans
and other developmental orthopaedic diseases that are thought to occur secondary to …

Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis

F Tóth, MJ Nissi, J Zhang, M Benson… - Journal of …, 2013 - Wiley Online Library
Cartilage canal vessels in epiphyseal cartilage have a pivotal role in the pathogenesis of
osteochondrosis/osteochondritis dissecans. The present study aimed to validate high field …

Multiparametric MRI of epiphyseal cartilage necrosis (osteochondrosis) with histological validation in a goat model

L Wang, MJ Nissi, F Tóth, J Shaver, CP Johnson… - PloS one, 2015 - journals.plos.org
Purpose To evaluate multiple MRI parameters in a surgical model of osteochondrosis (OC)
in goats. Methods Focal ischemic lesions of two different sizes were induced in the …

Evaluation of the suitability of miniature pigs as an animal model of juvenile osteochondritis dissecans

F Tóth, CP Johnson, B Mills, MJ Nissi… - Journal of …, 2019 - Wiley Online Library
Juvenile osteochondritis dissecans (JOCD) is a developmental disease characterized by
formation of intra‐articular (osteo) chondral flaps or fragments. Evidence‐based treatment …

[HTML][HTML] Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis

F Tóth, MJ Nissi, L Wang, JM Ellermann… - Osteoarthritis and …, 2015 - Elsevier
Objective Identify and interrupt the vascular supply to portions of the distal femoral articular-
epiphyseal cartilage complex (AECC) in goat kids to induce cartilage necrosis, characteristic …

[HTML][HTML] Juvenile osteochondritis dissecans of the knee is a result of failure of the blood supply to growth cartilage and osteochondrosis

K Olstad, KG Shea, PC Cannamela, JD Polousky… - Osteoarthritis and …, 2018 - Elsevier
Objective Juvenile osteochondritis dissecans (JOCD) is similar to osteochondrosis
dissecans (OCD) in animals, which is the result of failure of the cartilage canal blood supply …

An update on the pathogenesis of osteochondrosis

K Olstad, S Ekman, CS Carlson - Veterinary pathology, 2015 - journals.sagepub.com
Osteochondrosis is defined as a focal disturbance in endochondral ossification. The
cartilage superficial to an osteochondrosis lesion can fracture, giving rise to fragments in …

[HTML][HTML] MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T

KD Ludwig, CP Johnson, Š Zbýň, A Nowacki… - Osteoarthritis and …, 2020 - Elsevier
Objective Evaluate articular cartilage by magnetic resonance imaging (MRI) T2∗ mapping
within the distal femur and proximal tibia in adolescents with juvenile osteochondritis …