To examine the stimulus-secretion response of human pituitary gonadotrophs in vivo, we
applied a new multiple parameter deconvolution technique to analyze (1) exogenous GnRH …

Previous investigations of the effects of GnRH on pituitary LH responses in normal men
required pharmacological doses of GnRH to avoid the confounding effects of endogenous …

The effects of increasing the frequency of pulsatile GnRH administration on LH and FSH
responsiveness were studied in five GnRH-deficient men who had achieved normal sex …

THE TONIC and cyclic secretion of gonadotropins is mediated by the hypothalamic
production of gonadotropin releasing hormone (GnRH). The direct assessment of …

To investigate the contribution of hypothalamic gonadotropin-releasing hormone (GnRH)
secretion to the midcycle gonadotropin surge in the human, the response of luteinizing …

The dynamics of LH secretion and clearance were studied in vivo in eight healthy young
men using a novel multiple parameter deconvolution procedure to resolve underlying …

Publisher Summary This chapter discusses the physiology of gonadotropin-releasing
hormone (GnRH) secretion in men and women. The study of the normal physiology of GnRH …

Although differences in plasma GnRH concentrations have been identified after iv and sc
injection of this peptide, differences in pituitary LH responses to iv and sc GnRH have not …

To examine the importance of the interpulse interval of gonadotropin-releasing hormone
(GnRH) stimulation in modulating gonadotroph responsiveness, a fixed individualized dose …

The pulse frequency, amplitude, and mode of administration of GnRH all influence
gonadotropin secretion and, ultimately, pituitary-gonadal function. We studied plasma LH …