Cell-free DNA in the blood as a solid tumor biomarker—a critical appraisal of the literature

K Jung, M Fleischhacker, A Rabien - Clinica chimica acta, 2010 - Elsevier
Circulating cell-free DNA (cfDNA) has been suggested as a cancer biomarker. Several
studies assessed the usefulness of quantitative and qualitative tumor-specific alterations of …

Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance

E Gormally, E Caboux, P Vineis, P Hainaut - Mutation Research/Reviews in …, 2007 - Elsevier
The presence of small amounts of tumor DNA in cell free DNA (CFDNA) circulating in the
plasma or serum of cancer patients was first demonstrated 30 years ago. Since then, overall …

Optimizing the yield and utility of circulating cell-free DNA from plasma and serum

X Xue, MD Teare, I Holen, YM Zhu, PJ Woll - Clinica chimica acta, 2009 - Elsevier
BACKGROUND: Cell-free DNA (CFDNA) in the plasma/serum of patients with cancer
demonstrates tumour-associated genetic alterations, offering possibilities for diagnosis …

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients

DM Marzese, H Hirose, DSB Hoon - Expert review of molecular …, 2013 - Taylor & Francis
Qualitative and quantitative analysis of circulating cell-free DNA (cfDNA) is an emerging non-
invasive blood biomarker utilized to assess tumor progression and to evaluate prognosis …

Cell-free DNA as a diagnostic marker for cancer: current insights

S Salvi, G Gurioli, U De Giorgi, V Conteduca… - Oncotargets and …, 2016 - Taylor & Francis
The increasing knowledge of the molecular pathogenesis of cancer and the rapid
development of new molecular techniques are promoting the study of early molecular …

Preanalytical variables that affect the outcome of cell-free DNA measurements

V Ungerer, AJ Bronkhorst… - Critical Reviews in Clinical …, 2020 - Taylor & Francis
Fragments of cell-free DNA (cfDNA) in human body fluids often carry disease-specific
alterations and are now widely recognized as ideal biomarkers for the detection and …

Cell-free DNA: hope and potential application in cancer

Y Yan, Q Guo, F Wang, R Adhikari, Z Zhu… - Frontiers in cell and …, 2021 - frontiersin.org
Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as
biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA …

Cell-free DNA: measurement in various carcinomas and establishment of normal reference range

TL Wu, D Zhang, JH Chia, KC Tsao, CF Sun, JT Wu - Clinica chimica acta, 2002 - Elsevier
Background: Cell-free DNA is detectable in circulating blood. Numerous reports in the
literature have pointed out that cell-free DNA in plasma or serum has the clinical potential to …

Cell-free DNA in the circulation as a potential cancer biomarker

C Kohler, Z Barekati, R Radpour… - Anticancer research, 2011 - ar.iiarjournals.org
In the course of the search for new biomarkers, circulating cell-free DNA (ccf-DNA) has
become a popular target of interest. An elevated level of ccf-DNA has been detected in the …

The long and short of circulating cell-free DNA and the ins and outs of molecular diagnostics

P Jiang, YMD Lo - Trends in Genetics, 2016 - cell.com
The discovery of cell-free tumor and fetal DNA molecules in the plasma of cancer patients
and pregnant women, respectively, has opened up exciting opportunities in molecular …