Relevance of animal studies in the toxicological assessment of oil and wax hydrocarbons. Solving the puzzle for a new outlook in risk assessment
JC Carrillo, D Danneels, J Woldhuis - Critical Reviews in …, 2021 - Taylor & Francis
Paraffin waxes and white mineral oils are distinct petroleum products separated from a
common feedstock by crystallization, where only n-alkanes, iso-and cyclo-alkanes with a …
common feedstock by crystallization, where only n-alkanes, iso-and cyclo-alkanes with a …
Evaluating the MoA/human relevance framework for F-344 rat liver epithelioid granulomas with mineral oil hydrocarbons
Toxicology feeding studies of mineral oil hydrocarbons (MOHs), within the carbon number
range C22–C28, results in species-specific epithelioid granulomas in the liver of F-344 rats …
range C22–C28, results in species-specific epithelioid granulomas in the liver of F-344 rats …
Update of the risk assessment of mineral oil hydrocarbons in food
EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2023 - Wiley Online Library
Mineral oil hydrocarbons (MOH) are composed of saturated hydrocarbons (MOSH) and
aromatic hydrocarbons (MOAH). Due to the complexity of the MOH composition, their …
aromatic hydrocarbons (MOAH). Due to the complexity of the MOH composition, their …
Mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats; accumulation of wax components; implications for risk assessment
L Barp, M Biedermann, K Grob, F Blas-Y-Estrada… - Science of the Total …, 2017 - Elsevier
Female Fischer 344 rats were exposed to three MOSH mixtures: oils largely below and
above C 25 (S-C25 and L-C25) and a 1: 1 mixture of L-C25 with a wax; doses of 400, 1000 …
above C 25 (S-C25 and L-C25) and a 1: 1 mixture of L-C25 with a wax; doses of 400, 1000 …
[HTML][HTML] Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils
JC Carrillo, L Kamelia, J Romanuka, O Kral… - Regulatory Toxicology …, 2022 - Elsevier
The carcinogenicity and developmental toxicity of unrefined mineral oil is related to its 3–7
ring polycyclic aromatic compounds (PAC) content. Therefore, refining operations focus on …
ring polycyclic aromatic compounds (PAC) content. Therefore, refining operations focus on …
Toxic effects of mineral oil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver
UC Nygaard, Å Vege, T Rognum, K Grob… - Food and Chemical …, 2023 - Elsevier
Humans are daily exposed to mineral oil saturated hydrocarbons (MOSH) from the diet. We
exposed female Fischer 344 rats to a broad mixture and sub-fractions of MOSH. Chemical …
exposed female Fischer 344 rats to a broad mixture and sub-fractions of MOSH. Chemical …
[HTML][HTML] Lack of human-relevant adversity of MOSH retained in tissues: Analysis of adversity and implications for regulatory assessment
AL Isola, JC Carrillo, P Lemaire, H Niemelä… - Regulatory Toxicology …, 2023 - Elsevier
Mineral oils (food grade white oil or liquid paraffin) have historically been safely used in a
number of sensitive end-uses, including pharmaceutical, cosmetic and food. Recent concern …
number of sensitive end-uses, including pharmaceutical, cosmetic and food. Recent concern …
A study of the toxicity of five mineral hydrocarbon waxes and oils in the F344 rat, with histological examination and tissue-specific chemical characterisation of …
MJ Scotter, L Castle, RC Massey, PG Brantom… - Food and chemical …, 2003 - Elsevier
Five food-grade mineral hydrocarbon (MHC) materials; a low melting point wax (LMPW), a
synthetic wax (C80W) and three white oils (N15H, N70H and P70H) were administered …
synthetic wax (C80W) and three white oils (N15H, N70H and P70H) were administered …
Toxic effects of mineral oil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver
UC Nygaard, Å Vege, T Rognum, K Grob… - Food and Chemical …, 2019 - Elsevier
Humans are daily exposed to mineral oil saturated hydrocarbons (MOSH) from the diet. We
exposed female Fischer 344 rats to a broad mixture and sub-fractions of MOSH. Chemical …
exposed female Fischer 344 rats to a broad mixture and sub-fractions of MOSH. Chemical …
Evaluating the risk to humans from mineral oils in foods: Current state of the evidence
R Bevan, PTC Harrison, B Jeffery, D Mitchell - Food and Chemical …, 2020 - Elsevier
Key issues around the evaluation of risks to humans from mineral oils in food and feedstuffs
are discussed. MOHs (MOAH and MOSH) occur in food due to intentional use …
are discussed. MOHs (MOAH and MOSH) occur in food due to intentional use …