Prevalence of preclinical Alzheimer disease: Comparison of current classification systems

S Kern, H Zetterberg, J Kern, A Zettergren, M Waern… - Neurology, 2018 - AAN Enterprises
Objective To determine the prevalence of preclinical Alzheimer disease (AD) according to
current classification systems by examining CSF from a representative general population …

Alzheimer disease as a clinical-biological construct—an International Working Group recommendation

B Dubois, N Villain, L Schneider, N Fox… - JAMA …, 2024 - jamanetwork.com
Importance Since 2018, a movement has emerged to define Alzheimer disease (AD) as a
purely biological entity based on biomarker findings. The recent revision of the Alzheimer's …

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

SJB Vos, C Xiong, PJ Visser, MS Jasielec… - The Lancet …, 2013 - thelancet.com
Background New research criteria for preclinical Alzheimer's disease have been proposed,
which include stages for cognitively normal individuals with abnormal amyloid markers …

Alzheimer's disease: What is it, how many people have it, and why do we need to know?

MS Albert, DA Drachman - Neurology, 2000 - AAN Enterprises
In 1907, when Alois Alzheimer first described the clinical and pathologic findings in the case
of 54-year-old Auguste D., her severe and progressive dementia had been grossly obvious …

Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset

J Saxton, OL Lopez, G Ratcliff, C Dulberg, LP Fried… - Neurology, 2004 - AAN Enterprises
Objective: To determine if individuals ultimately diagnosed with Alzheimer disease (AD)
exhibited evidence of cognitive impairment on neuropsychological tests administered …

A brief history of “Alzheimer disease” Multiple meanings separated by a common name

DS Knopman, RC Petersen, CR Jack Jr - Neurology, 2019 - AAN Enterprises
The field of Alzheimer disease (AD) has a nosologic problem: The diagnostic label
“Alzheimer disease” has several distinctive meanings. The term probable AD was …

Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I

OL Lopez, JT Becker, W Klunk, J Saxton, RL Hamilton… - Neurology, 2000 - AAN Enterprises
Objective: To describe the experience of a research clinic diagnosing AD during the last two
decades, with special emphasis on patients who meet the National Institute of Neurological …

Fitting the epidemiology and neuropathology of the early stages of Alzheimer's disease to prevent dementia

J Mar, M Soto-Gordoa, A Arrospide… - Alzheimer's research & …, 2015 - Springer
Introduction Recent research on biomarkers has made possible the diagnosis of pre-
dementia and even preclinical Alzheimer's disease (AD), thus providing the ideal context for …

Epidemiology of Alzheimer disease

C Reitz, C Brayne, R Mayeux - Nature Reviews Neurology, 2011 - nature.com
The global prevalence of dementia is estimated to be as high as 24 million, and is predicted
to double every 20 years through to 2040, leading to a costly burden of disease. Alzheimer …

Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease

DS Knopman, CR Jack Jr, HJ Wiste, SD Weigand… - Neurology, 2012 - AAN Enterprises
Objective: Recommendations for the diagnosis of preclinical Alzheimer disease (AD) have
been formulated by a workgroup of the National Institute on Aging and Alzheimer's …