Thy-1, an abundant mammalian glycoprotein, interacts with αvβ3 integrin and syndecan-4 in
astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK …

Our previous reports indicate that ligand-induced α V β 3 integrin and Syndecan-4
engagement increases focal adhesion formation and migration of astrocytes. Additionally …

Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins
that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin …

Clustering of αvβ3 integrin after interaction with the RGD-like integrin-binding sequence
present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in …

Background: Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such
prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand …

Thy-1, a cell adhesion molecule abundantly expressed in mammalian neurons, binds to a β
3-containing integrin on astrocytes and thereby stimulates the assembly of focal adhesions …

Thy-1 is an abundant neuronal glycoprotein of poorly defined function. We recently provided
evidence indicating that Thy-1 clusters a β3-containing integrin in astrocytes to induce …

Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1
function remains largely obscure in the absence of a defined ligand. Recently described …

Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory
phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) play an …

Two key proteins for cellular communication between astrocytes and neurons are αvβ3
integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent …