Background The contribution of hypercoagulability to the pathophysiology of sickle cell
disease (SCD) remains poorly defined. We sought to evaluate the association of markers of …

Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet
activation, high plasma levels of markers of thrombin generation, depletion of natural …

Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting
millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and …

Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin
generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic …

VTE is an underappreciated and potentially morbid complication of SCD. The mechanisms
underlying this hypercoagulable state are complex. A greater understanding of these …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Bleeding is a known complication of sickle cell disease (SCD) and includes hemorrhagic
stroke, hematuria, and vitreous hemorrhage. However, the incidence of bleeding events in …

Recent evidence suggests that sickle cell disease (SCD) can be consideced a
hypercoagulable state, in which both platelet activation and thiombin generation are …

Sickle cell disease is the most common inherited haematological disorder that leads to the
irreversible damage of multiple organs. Although sickling of red blood cells and vaso …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …