The existence of constitutive activity for G protein-coupled receptors (GPCRs) was first
described in 1980s. In 1991, the first naturally occurring constitutively active mutations in …

Activating and inactivating mutations in numerous human G protein-coupled receptors
(GPCRs) are associated with a wide range of disease phenotypes. Here we use several …

G protein–coupled receptors (GPCRs) respond to a chemically diverse plethora of signal
transduction molecules. The notion that GPCRs also signal without an external chemical …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

Genetic variation in G protein-coupled receptors (GPCRs) results in the disruption of GPCR
function in a wide variety of human genetic diseases. In vitro strategies have been used to …

During the past 10 years or so, associated with the introduction of molecular biology
techniques to G protein coupled receptor (GPCR) research, outstanding progress has been …

The aim of this review is to provide a systematic overview on constitutively active G-protein-
coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

The superfamily of G protein‐coupled receptors (GPCRs) is the largest and most diverse
group of transmembrane proteins involved in signal transduction. Many of the over 1000 …