The purpose of the present study was to assess the impact of smoking on the metabolism of
psychotropic drugs in a group of patients with schizophrenia, by measuring CYP1A2 activity …

CYP2D6 has been suggested to be functionally similar to the dopamine transporter. The
present study was aimed at analysing the frequency of CYP2D6 alleles and genotype …

Introduction: Genetic polymorphisms of cytochrome P450 (CYP) may predict the treatment
response or occurrence of side effects of antipsychotic drugs. Aim: We studied the …

Clozapine is an atypical antipsychotic drug and displays efficacy in 30% to 60% of patients
with schizophrenia who do not respond to traditional antipsychotics. A clozapine …

This study investigated whether the smokinginducible cytochrome P450 (CYP) 1A2 and the
polymorphic CYP2D6 play significant roles in the metabolism of olanzapine and its clinical …

According to the literature, there is an association between schizophrenia and caffeine
consumption, but it is not clear whether schizophrenia is associated with either higher …

Objective Cigarette smoking has been shown in several studies to induce the metabolism of
the cytochrome P4501A2 (CYP1A2) substrates clozapine and olanzapine. The aim of the …

Study Objective. To investigate whether a relationship exists between the most common
known cytochrome P450 (CYP) isozyme 2D6 mutations and schizophrenia. Because most …

Objective: The aim of the present retrospective pilot study was to examine the clinical impact
of the cytochrome P450 (CYP) enzyme CYP2D6 poor metabolizer (PM) genotype in patients …

The use of classic anti-psychotic drugs in the long-term treatment of schizophrenia is
associated with risk for extrapyramidal side-effects, such as akathisia, parkinsonism and …