Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4
EC Row, SA Brown, AV Stachulski… - Bioorganic & medicinal …, 2006 - Elsevier
Furanocoumarins have been shown to inhibit CYP3A4 in vitro with varying degrees of
potency [Pharmacogenetics1997, 7, 391–396; Chem. Res. Toxicol. 1998, 11, 252–259; …
potency [Pharmacogenetics1997, 7, 391–396; Chem. Res. Toxicol. 1998, 11, 252–259; …
Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4
EC Row, SA Brown, AV Stachulski… - Organic & biomolecular …, 2006 - pubs.rsc.org
A number of furanocoumarins isolated from grapefruit juice have been found to inhibit
CYP3A4 activity in vitro. In this study, we have designed and synthesised a range of …
CYP3A4 activity in vitro. In this study, we have designed and synthesised a range of …
Different modes of inhibition of mouse Cyp2a5 and rat CYP2A3 by the food-derived 8-methoxypsoralen
S Visoni, N Meireles, L Monteiro, A Rossini… - Food and chemical …, 2008 - Elsevier
CYP2A enzymes are responsible for nicotine metabolism and for activating tobacco-related
carcinogens. Inhibition of CYP2A is a promising approach in chemoprevention, which could …
carcinogens. Inhibition of CYP2A is a promising approach in chemoprevention, which could …
Synthesis of novel psoralen analogues and their in vitro antitumor activity
CS Francisco, LR Rodrigues, NM Cerqueira… - Bioorganic & medicinal …, 2013 - Elsevier
New tetracyclic benzofurocoumarin (benzopsoralen) analogues were synthesized and their
inhibitory effect on the growth of tumor cell lines was evaluated. The human tumor cell lines …
inhibitory effect on the growth of tumor cell lines was evaluated. The human tumor cell lines …
Metabolic interactions of methoxsalen and coumarin in humans and mice
J Mäenpää, R Juvonen, H Raunio, A Rautio… - Biochemical …, 1994 - Elsevier
Abstract Methoxsalen (8-methoxypsoralen) is a very potent inhibitor of human cytochrome
P450 2A6 (CYP2A6) and mouse Cyp2a-5-mediated coumarin 7-hydroxylation in vitro. To …
P450 2A6 (CYP2A6) and mouse Cyp2a-5-mediated coumarin 7-hydroxylation in vitro. To …
Mechanism-based inactivation of P450 2A6 by furanocoumarins
LL Koenigs, WF Trager - Biochemistry, 1998 - ACS Publications
Several furanocoumarins were tested for their ability to inhibit human P450 2A6 activity. The
metabolites and conjugates formed from these furanocoumarins after incubation with …
metabolites and conjugates formed from these furanocoumarins after incubation with …
Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6* 15, CYP2A6* 16, CYP2A6* 21 and CYP2A6* 22: differential …
Human cytochrome P450 2A6 (CYP2A6) is a highly polymorphic isoform of CYP2A
subfamily. Our previous kinetic study on four CYP2A6 allelic variants (CYP2A6* 15 …
subfamily. Our previous kinetic study on four CYP2A6 allelic variants (CYP2A6* 15 …
Synthetic models related to furanocoumarin–CYP 3A4 interactions. Comparison of furanocoumarin, coumarin, and benzofuran dimers as potent inhibitors of CYP3A4 …
K Oda, Y Yamaguchi, T Yoshimura, K Wada… - Chemical and …, 2007 - jstage.jst.go.jp
Furanocoumarin derivatives (dimers and monomers) present in commercially available
grapefruit juice have the capacity to inhibit the activity of human CYP3A4. Such interactions …
grapefruit juice have the capacity to inhibit the activity of human CYP3A4. Such interactions …
Dihydroxybergamottin caproate as a potent and stable CYP3A4 inhibitor
T Ohta, M Nagahashi, S Hosoi, S Tsukamoto - Bioorganic & medicinal …, 2002 - Elsevier
We investigated the inhibitory activity of the furanocoumarin derivatives from grapefruit juice
to the drug metabolizing enzyme, cytochrome P450 (CYP) 3A4. Although two known …
to the drug metabolizing enzyme, cytochrome P450 (CYP) 3A4. Although two known …