Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …

Codon usage biases are found in all eukaryotic and prokaryotic genomes and have been
proposed to regulate different aspects of translation process. Codon optimality has been …

Synonymous codons encode the same amino acid, but differ in other biophysical properties.
The evolutionary selection of codons whose properties are optimal for a cell generates the …

The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …

Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

The genetic code is degenerate, and most amino acids are encoded by two to six
synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a …

Cellular efficiency in protein translation is an important fitness determinant in rapidly growing
organisms. It is widely believed that synonymous codons are translated with unequal …

Rapid cell growth demands fast protein translational elongation to alleviate ribosome
shortage. However, speedy elongation undermines translational accuracy because of a …

Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and plays
an important role in regulating gene expression levels. A major role of codon usage is …

Although the genetic code is redundant, synonymous codons for the same amino acid are
not used with equal frequencies in genomes, a phenomenon termed “codon usage bias.” …