Saccharomyces cerevisiae Contains an RNase MRP That Cleaves at a Conserved Mitochondrial RNA Sequence Implicated in Replication Priming
LL Stohl, DA Clayton - Molecular and cellular biology, 1992 - Taylor & Francis
Yeast mitochondrial DNA contains multiple promoters that sponsor different levels of
transcription. Several promoters are individually located immediately adjacent to presumed …
transcription. Several promoters are individually located immediately adjacent to presumed …
Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability …
ME Schmitt, DA Clayton - Genes & development, 1992 - genesdev.cshlp.org
RNase MRP is a site-specific ribonucleoprotein endoribonuclease that cleaves RNA
sequence complementary to mammalian mitochondrial origins of replication in a manner …
sequence complementary to mammalian mitochondrial origins of replication in a manner …
Nuclear RNase MRP is Required for Correct Processing of pre-5.8S rRNA in Saccharomyces cerevisiae
ME Schmitt, DA Clayton - Molecular and cellular biology, 1993 - Taylor & Francis
RNase MRP is a site-specific ribonucleoprotein endoribonuclease that cleaves RNA from
the mitochondrial origin of replication in a manner consistent with a role in priming leading …
the mitochondrial origin of replication in a manner consistent with a role in priming leading …
Initiation of mitochondrial DNA replication by transcription and R-loop processing
DY Lee, DA Clayton - Journal of Biological Chemistry, 1998 - ASBMB
The mitochondrial genome of eukaryotic cells is maintained by a mechanism distinct from
that employed in the nucleus. Mitochondrial DNA replication at the leading-strand origin is …
that employed in the nucleus. Mitochondrial DNA replication at the leading-strand origin is …
A functional dominant mutation in Schizosaccharomyces pombe RNase MRP RNA affects nuclear RNA processing and requires the mitochondrial‐associated nuclear …
JL Paluh, DA Clayton - The EMBO Journal, 1996 - embopress.org
The essential gene for RNase MRP RNA, mrp1, was identified previously in
Schizosaccharomyces pombe by homology to mammalian RNase MRP RNAs. Here we …
Schizosaccharomyces pombe by homology to mammalian RNase MRP RNAs. Here we …
Conserved features of yeast and mammalian mitochondrial DNA replication
ME Schmitt, DA Clayton - Current Opinion in Genetics & Development, 1993 - Elsevier
Mammalian mitochondrial DNA replication is initiated by the processing of RNA transcripts
derived from an upstream promoter to create RNA primers for DNA replication. In the yeast …
derived from an upstream promoter to create RNA primers for DNA replication. In the yeast …
A nuclear function for RNase MRP.
DA Clayton - Proceedings of the National Academy of …, 1994 - National Acad Sciences
The site-specific endoribonuclease RNase MRP was first identified 7 years ago as an RNA-
processing activity in mammalian cells (1, 2). In the original description of this …
processing activity in mammalian cells (1, 2). In the original description of this …
RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication.
DY Lee, DA Clayton - Genes & development, 1997 - genesdev.cshlp.org
The precursor primer RNA for mammalian mitochondrial DNA leading-strand replication
remains as a persistent R loop formed during transcription through the mitochondrial DNA …
remains as a persistent R loop formed during transcription through the mitochondrial DNA …
Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP
JN Topper, DA Clayton - Nucleic acids research, 1990 - academic.oup.com
Vertebrate cells contain a site-specific endoribonuclease (RNase MRP) that cleaves
mitochondrial RNA transcribed from the origin of leading-strand mitochondrial DNA …
mitochondrial RNA transcribed from the origin of leading-strand mitochondrial DNA …
Efficient site-specific cleavage by RNase MRP requires interaction with two evolutionarily conserved mitochondrial RNA sequences
JL Bennett, DA Clayton - Molecular and cellular biology, 1990 - Taylor & Francis
RNase MRP is a site-specific endonuclease that processes primer mitochondrial RNA from
the leading-strand origin of mitochondrial DNA replication. Using deletional analysis and …
the leading-strand origin of mitochondrial DNA replication. Using deletional analysis and …