Superactive analogues of gonadotrophin releasing hormone and testosterone, when
administered together, synergistically inhibit gonadotrophin secretion and spermatogenesis …

Chronic treatment with agonist analogs of GnRH results in reversible oligospermia i man,
but leads to impotence and decreased libido due to a concomitant fall in serum testosterone …

Constant infusion of GnRH agonist (GnRH-A) leads to far greater suppression of
spermatogenesis and gonadotropins in the monkey than its intermittent administration. We …

The effects of a potent gonadotrophin-releasing hormone (GnRH) antagonist,(N-Ac-dp-Cl-
Phe 1, 2, d-Trp 3, d-Arg 6, d-Ala 10)-GnRH (Org 30276), on pituitary and testicular function of …

Observations that hypophysectomized men demonstrate predictable azoospermia have led
to attempts to suppress gonadotropin secretion with drugs for contraceptive purposes …

Although hormonal regimens provide effective, reversible contraception for women, no
effective hormonal contraceptive regimen has yet been developed for men. Testosterone …

Synthetic long-acting agonistic analogs of GnRH both stimulate and paradoxically inhibit
gonadotropin secretion in male animals and humans. To characterize the stimulatory and …

GnRH long acting agonists, when given chronically, are potent inhibitors of testicular
function in both man and experimental animals. Administration of these agents to male rats …

GnRH analogues are classified as either agonists or antagonists based on their acute
response. The agonists were initially developed as therapeutic agents to stimulate LH and …

GnRH antagonists plus testosterone (T) suppress LH and FSH levels and inhibit
spermatogenesis to azoospermia or severe oligozoospermia. High-dose T treatment alone …