Major depressive disorder and the anxiety disorders are highly prevalent, disabling and
moderately heritable. Depression and anxiety are also highly comorbid and have a strong …

BackgroundAnxiety disorders are common, and cognitive–behavioural therapy (CBT) is a
first-line treatment. Candidate gene studies have suggested a genetic basis to treatment …

Major depressive disorder is heritable and a leading cause of disability. Cognitive behavior
therapy is an effective treatment for major depression. By quantifying genetic risk scores …

Objectives: Exposure-based cognitive behavioural therapy (eCBT) is an effective treatment
for anxiety disorders. Response varies between individuals. Gene expression integrates …

Exposure-based psychological treatments for anxiety have high efficacy. However, a
substantial proportion of patients do not respond to therapy. Research examining the …

Objective: To examine the effectiveness of genetic testing in a real-world setting and to
assess its impact on clinician treatment decisions. Method: This was a naturalistic …

Considerable variation is evident in response to psychological therapies for mood and
anxiety disorders. Genetic factors alongside environmental variables and gene-environment …

Pharmacogenetic testing is a useful and increasingly widespread tool to assist in
antidepressant prescription. More than ten antidepressants (including tricyclics, selective …

We conducted the first genome-wide association study (GWAS) in Generalized Anxiety
Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety …

Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are associated
with significant morbidity/mortality risk. Prolonged episodes increase impact on quality of life …