We address the recent debate surrounding the ability of 2, 4-difluorotoluene (F), a low-
polarity mimic of thymine (T), to form a hydrogen-bonded complex with adenine in DNA. The …

Recent experiments have shown that difluorotoluene (F), a nonpolar isostere for thymine (T),
codes efficiently and specifically for adenine (A) in DNA replication. F has almost the same …

Calculations were run on the methylated DNA base pairs adenine: thymine and adenine:
difluorotoluene to further investigate the hydrogen-bonding properties of difluorotoluene (F) …

The ability to determine the stability of non-Watson− Crick base pairs in DNA by computer
simulation is a necessary prerequisite for quantitative theoretical studies of DNA replication …

Efficiency of 6-ethynylpyridone (E), a potential thymine (T) analogue, which forms high-
fidelity base pairs with adenine (A) and gives rise to stabler DNA duplexes, with stability …

Noncovalent interactions between aromatic molecules are widely believed to be important
contributing factors in the stabilization of organized structure in biological macromolecules …

The level of interest in probing the strength of noncovalent interactions in DNA duplexes is
high, as these weak forces dictate the range of suprastructures the double helix adopts …

Up till now, there has been a significant disagreement between theory and experiment
regarding hydrogen bond lengths in Watson− Crick base pairs. To investigate the possible …

The discovery by Kool and co-workers that 2, 4-difluorotoluene (F) mimics thymine (T) in
DNA replication has led to a controversy about the question if this mimic has the capability of …

We describe the structure in aqueous solution of a DNA duplex containing a base pair that is
structurally analogous to A− T but which lacks hydrogen bonds. Base analogues F (a …