Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell‐derived extracellular vesicles

DB Patel, KM Gray, Y Santharam… - Bioengineering & …, 2017 - Wiley Online Library
Mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) have emerged as
potential therapeutic agents for numerous applications. EVs offer potential advantages over …

Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions

C Almeria, S Kreß, V Weber, D Egger, C Kasper - Cell & Bioscience, 2022 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in
physiological as well as pathological processes by functioning as vehicles for the delivery of …

Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications

D Tsiapalis, L O'Driscoll - Cells, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in
tissue engineering and regenerative medicine. However, recent evidence suggests that the …

Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications

T Williams, G Salmanian, M Burns, V Maldonado… - Biochimie, 2023 - Elsevier
Mesenchymal stem/stromal cells (MSCs) are multipotent somatic cells that have been widely
explored in the field of regenerative medicine. MSCs possess the ability to secrete soluble …

Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications

A Gowen, F Shahjin, S Chand, KE Odegaard… - Frontiers in cell and …, 2020 - frontiersin.org
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …

Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

KS Park, E Bandeira, GV Shelke, C Lässer… - Stem cell research & …, 2019 - Springer
After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell
therapy, there was increased interest in their secreted soluble factors. Following studies of …

Scaled isolation of mesenchymal stem/stromal cell‐derived extracellular vesicles

V Börger, S Staubach, R Dittrich… - Current protocols in …, 2020 - Wiley Online Library
Mesenchymal stem/stromal cells (MSCs) provide therapeutic effects in many diseases.
Contrary to initial hypotheses, they act in a paracrine rather than a cellular manner. To this …

Effect of 2D and 3D culture microenvironments on mesenchymal stem cell-derived extracellular vesicles potencies

GD Kusuma, A Li, D Zhu, H McDonald… - Frontiers in Cell and …, 2022 - frontiersin.org
Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …

Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system

J Rezaie, V Nejati, M Mahmoodi, M Ahmadi - Biochemical Pharmacology, 2022 - Elsevier
An ideal drug delivery system should selectively deliver incorporated therapeutics to the
target site, escape from immune cells recognition and degradation, and act controlled …