Sickle cell disease (SCD) is an hereditary disorder characterized by the production of an
abnormal hemoglobin called hemoglobin S (HbS). HbS may polymerize in deoxygenated …

Sickle cell disease (SCD) is a hereditary disorder that leads to the production of an
abnormal hemoglobin, hemoglobin S (HbS). HbS polymerizes in deoxygenated conditions …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

A homozygous mutation in the gene for β globin, a subunit of adult hemoglobin A (HbA), is
the proximate cause of sickle cell disease (SCD). Sickle hemoglobin (HbS) shows peculiar …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Sickle cell disease (SCD) is a monogenetic disorder caused by a mutation in the β-globin
gene HBB leading to polymerization of red blood cells causing damage to cell membranes …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …

Sickle cell disease (SCD) is an autosomal recessive disorder. Although the molecular
mechanisms at the origin of SCD have been well characterized, its clinical expression is …

Introduction In sickle cell disease (SCD), hemoglobin S (HbS) red blood cells (RBCs) are
characteristically deformed and inflexible. Often breaking down in the circulation, they …

Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …