Age-related macular degeneration: a high-resolution genome scan for susceptibility loci in a population enriched for late-stage disease

GR Abecasis, BM Yashar, Y Zhao… - The American Journal of …, 2004 - cell.com
Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the
central region of the retina. AMD is clinically heterogeneous, leading to geographic atrophy …

Age-related macular degeneration—a genome scan in extended families

J Majewski, DW Schultz, RG Weleber… - The American Journal of …, 2003 - cell.com
We performed a genomewide scan and genetic linkage analysis, to identify loci associated
with age-related macular degeneration (AMD). We collected 70 families, ranging from small …

Meta-analysis of genome scans of age-related macular degeneration

SA Fisher, GR Abecasis, BM Yashar… - Human molecular …, 2005 - academic.oup.com
A genetic contribution to the development of age-related macular degeneration (AMD) is
well established. Several genome-wide linkage studies have identified a number of putative …

A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions

JM Seddon, SL Santangelo, K Book, S Chong… - The American Journal of …, 2003 - cell.com
We report the results of a genomewide scan for age-related macular degeneration (AMD) in
158 multiplex families. AMD classification was based on fundus photography and was …

Genome-wide analysis of disease progression in age-related macular degeneration

Q Yan, Y Ding, Y Liu, T Sun, LG Fritsche… - Human molecular …, 2018 - academic.oup.com
Family-and population-based genetic studies have successfully identified multiple disease-
susceptibility loci for Age-related macular degeneration (AMD), one of the first batch and …

Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes

L Sobrin, S Ripke, Y Yu, J Fagerness, TR Bhangale… - Ophthalmology, 2012 - Elsevier
PURPOSE: To investigate whether the 2 subtypes of advanced age-related macular
degeneration (AMD), choroidal neovascularization (CNV), and geographic atrophy (GA) …

Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration

SK Iyengar, D Song, BEK Klein, R Klein… - The American Journal of …, 2004 - cell.com
To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative
disease of the retinal pigment epithelium and neurosensory retina, we conducted a …

Rare genetic variants associated with development of age-related macular degeneration

NTM Saksens, MJ Geerlings, B Bakker… - JAMA …, 2016 - jamanetwork.com
Importance Rare variants in the complement genesCFH, CFI, C9, andC3have been found to
be highly associated with age-related macular degeneration (AMD); however, the effect on …

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics

MB Gorin - Molecular aspects of medicine, 2012 - Elsevier
Age-related macular degeneration (AMD) is a common condition among the elderly
population that leads to the progressive central vision loss and serious compromise of …

Age-related macular degeneration: clinical features in a large family and linkage to chromosome 1q

ML Klein, DW Schultz, A Edwards… - Archives of …, 1998 - jamanetwork.com
Objectives To identify the chromosomal location of a disease-causing gene and to describe
the clinical characteristics of a large family with age-related macular degeneration (ARMD) …