To assess its gonadotropin-inhibiting potency in man, three different doses of a GnRH
antagonist ([Ac-D2-Nal1, d4-Cl-Phe2, d3-Pal3, Arg5, d4-p-methoxybenzoyl-2-amino butyric …

To study the dose response characteristics of a gonadotropin-releasing hormone (GnRH)
antagonist ([Ac-D 2-Nal 1, D 4-Cl-Phe 2, D 3-Pal 3, Arg 5, dGlu 6 (AA), d-Ala 10] GnRH; Nal …

The dose-response effects of a single administration of Nal-Lys-GnRHant (antagonist) on
serum LH and FSH concentrations were compared to the effects of Nal-Glu-GnRHant in …

Synthetic long-acting agonistic analogs of GnRH both stimulate and paradoxically inhibit
gonadotropin secretion in male animals and humans. To characterize the stimulatory and …

The suppressive effect of the gonadotropin-releasing hormone (GnRH) antagonist NalGlu
([Ac-D2Nal1, D4ClPhe2, D3Pal3, Arg5, D-4-p-methoxybenzoyl-2-aminobutyric acid6 …

Objective To test the hypothesis that over a 4-week treatment period, Nal-Glu GnRH
antagonist ([AcD2Nal 1, D4ClPhe 2, D3Pal 3, Arg 5, DGlu 6 [AA], DAla 10] GnRH) at a dose …

Constant infusion of GnRH agonist (GnRH-A) leads to far greater suppression of
spermatogenesis and gonadotropins in the monkey than its intermittent administration. We …

The differential regulation of immunoactive FSH and LH secretion by endogenous GnRH
was studied using a GnRH antagonist,[Ac-D2Nal1, d4FPhe2, dTrp3, dArg6] GnRH (the NAL …

The GnRH antagonist cetrorelix effectively suppresses serum LH, FSH, and testosterone (T)
in normal men without major side-effects. However, as with other available GnRH …

The inhibitory time course and dose-related characteristics of a new potent GnRH antagonist
peptide,[N-acetyl-dp Cl-Phe1, 2-d-Trp3-d-Lys6-d-Ala10] GnRH, on gonadotropin secretion …