[HTML][HTML] Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones

L Duart-Castells, N Nadal-Gratacós, M Muralter… - …, 2021 - Elsevier
The emergence of new synthetic cathinones continues to be a matter of public health
concern. In fact, they are quickly replaced by new structurally related alternatives. The main …

Structure–activity relationship of novel second-generation synthetic cathinones: Mechanism of action, locomotion, reward, and immediate-early genes

N Nadal-Gratacós, AS Alberto-Silva… - Frontiers in …, 2021 - frontiersin.org
Several new synthetic cathinones, which mimic the effect of classical psychostimulants such
as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In …

Structure–Activity Relationship of N-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral …

N Nadal-Gratacós, E Ríos-Rodríguez… - ACS Chemical …, 2023 - ACS Publications
Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased
dramatically in the past decades. N-Ethyl substituted cathinones have been proven to …

Interactions of cathinone NPS with human transporters and receptors in transfected cells

LD Simmler, ME Liechti - … of New Psychoactive Substances (NPS) The …, 2016 - Springer
Pharmacological assays carried out in transfected cells have been very useful for describing
the mechanism of action of cathinone new psychoactive substances (NPS). These in vitro …

Monoamine transporter and receptor interaction profiles of synthetic cathinones

LD Simmler - Synthetic cathinones: novel addictive and stimulatory …, 2018 - Springer
Cathinones are amphetamine-type substances with a β-keto substitution, typically emerging
as drugs of abuse among novel psychoactive substances (NPS). In vitro screenings have …

Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone

R López‐Arnau, J Martínez‐Clemente… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Here, we have compared the neurochemical profile of
three new cathinones, butylone, mephedrone and methylone, in terms of their potential to …

Understanding the pharmacokinetics of synthetic cathinones: Evaluation of the blood–brain barrier permeability of 13 related compounds in rats

D Fabregat‐Safont, M Barneo‐Muñoz… - Addiction …, 2021 - Wiley Online Library
Synthetic cathinones are the second most commonly seized new psychoactive substance
family in Europe. These compounds have been related to several intoxication cases …

Monoamine transporter and receptor interaction profiles of a new series of designer cathinones

LD Simmler, A Rickli, MC Hoener, ME Liechti - Neuropharmacology, 2014 - Elsevier
Psychoactive β-keto amphetamines (cathinones) are sold as “bath salts” or “legal highs” and
recreationally abused. We characterized the pharmacology of a new series of cathinones …

The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates

K Saha, Y Li, M Holy, KR Lehner, MO Bukhari… - …, 2019 - Springer
Rationale Synthetic cathinones continue to emerge in recreational drug markets worldwide.
1-(1, 3-Benzodioxol-5-yl)-2-(methylamino) butan-1-one (butylone) and 1-(1, 3-benzodioxol-5 …

Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives

N Nadal-Gratacos, E Lleixa, M Gibert-Serramia… - International Journal of …, 2022 - mdpi.com
Changes in the molecular structure of synthetic cathinones has led to an increase in the
number of novel emerging drugs in the illicit drug market at an unprecedented rate …