Mutations of receptor tyrosine kinases are implicated in the constitutive activation and
development of human malignancy. An internal tandem duplication (ITD) of the …

FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …

Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic
lesions in acute myeloid leukemia (AML) and are present in approximately one third of AML …

Internal tandem duplication (ITD) mutations of the juxtamembrane domain–coding sequence
of the FLT3 gene are found in up to 34% of patients with acute myeloid leukemia (AML) and …

Analysis of internal tandem duplications of FLT3 (FLT3/ITD) was performed on bone marrow
samples obtained at diagnosis and relapse from 108 adult patients with de novo acute …

FLT3, a member of the receptor tyrosine kinase (RTK) class III, is preferentially expressed on
the surface of a high proportion of acute myeloid leukemia (AML) and B-lineage acute …

FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML).
About 30 to 35% of patients have either internal tandem duplications (ITDs) in the …

Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most
frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a …

Mutations in the juxtamembrane and kinase domains of FLT3 are common in AML, but it is
not known whether alterations outside these regions contribute to leukemogenesis. We used …

Somatic mutation of the FLT3 gene, in which the juxtamembrane domain has an internal
tandem duplication, is found in 20% of human acute myeloid leukemias and causes …