To investigate retroviral integration targeting on a nucleotide scale, we examined the base
frequencies directly surrounding cloned in vivo HIV-1, murine leukemia virus, and avian …

The completion of the human genome sequence has made possible genome-wide studies
of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences …

Retroviral integration into the host genome is not entirely random, and integration site
preferences vary among different retroviruses. Human immunodeficiency virus (HIV) prefers …

Retroviruses differ in their preferences for sites for viral DNA integration in the chromosomes
of infected cells. Human immunodeficiency virus (HIV) integrates preferentially within active …

The chromosomal features that influence retroviral integration site selection are not well
understood. Here, we report the mapping of 226 avian sarcoma virus (ASV) integration sites …

Factors contributing to retroviral integration have been intractable because past studies
have not precisely located genomic sites of proviruses in sufficient numbers for significant …

Integration into the host genome is one of the hallmarks of the retroviral life cycle and is
catalyzed by virus-encoded integrases. While integrase has strict sequence requirements for …

Retroviral vectors are popular vehicles for gene transfer, since they neatly integrate a single
copy of a new gene into a transduced cell. The viral cDNA that becomes integrated is …

Based on integration site preferences, retroviruses can be placed into three groups. Viruses
that comprise the first group, murine leukemia virus and foamy virus, integrate preferentially …

The choice of retroviral integration sites is strongly influenced by chromatin: integration in
vitro occurs more efficiently into nucleosomal DNA than into naked DNA, and a characteristic …