Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung

X Wang, T Xia, S Addo Ntim, Z Ji, S Lin, H Meng… - ACS …, 2011 - ACS Publications
We developed a dispersal method for multiwalled carbon nanotubes (MWCNTs) that allows
quantitative assessment of dispersion on profibrogenic responses in tissue culture cells and …

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

J Dong, DW Porter, LA Batteli, MG Wolfarth… - Archives of …, 2015 - Springer
Multi-walled carbon nanotubes (MWCNT) are new materials with a wide range of industrial
and commercial applications. However, their nano-scaled size and fiber-like shape render …

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

H Barosova, AG Maione, D Septiadi, M Sharma… - Acs Nano, 2020 - ACS Publications
Expansion in production and commercial use of nanomaterials increases the potential
human exposure during the lifecycle of these materials (production, use, and disposal) …

Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts

L Wang, RR Mercer, Y Rojanasakul, A Qiu… - Journal of Toxicology …, 2010 - Taylor & Francis
Nanomaterials, including single-walled carbon nanotubes (SWCNT), are being developed
for a variety of commercial products. However, adverse health effects attributed to these new …

Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of …

JB Mangum, EA Turpin, A Antao-Menezes… - Particle and fibre …, 2006 - Springer
Background Nanotechnology is a rapidly advancing industry with many new products
already available to the public. Therefore, it is essential to gain an understanding of the …

Multiwall carbon nanotubes directly promote fibroblast–myofibroblast and epithelial–mesenchymal transitions through the activation of the TGF‐β/Smad signaling …

P Wang, Y Wang, X Nie, C Braïni, R Bai, C Chen - Small, 2015 - Wiley Online Library
A number of studies have demonstrated that MWCNTs induce granuloma formation and
fibrotic responses in vivo, and it has been recently reported that MWCNT‐induced …

Effect of fiber length on carbon nanotube-induced fibrogenesis

A Manke, S Luanpitpong, C Dong, L Wang… - International journal of …, 2014 - mdpi.com
Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily
inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly …

Mechanisms of carbon nanotube‐induced pulmonary fibrosis: a physicochemical characteristic perspective

KS Duke, JC Bonner - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Carbon nanotubes (CNTs) are engineered nanomaterials (ENMs) with numerous beneficial
applications. However, they could pose a risk to human health from occupational or …

Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF‐β/Smad signaling pathway

P Wang, X Nie, Y Wang, Y Li, C Ge, L Zhang, L Wang… - Small, 2013 - Wiley Online Library
Multiwall carbon nanotubes (MWCNTs) have been widely used in many disciplines due to
their unique physical and chemical properties, but have also raised great concerns about …

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis

J Dong, Q Ma - Nanotoxicology, 2018 - Taylor & Francis
Pulmonary exposure to carbon nanotubes (CNTs) induces fibrosing lesions in the lungs that
manifest rapid-onset inflammatory and fibrotic responses, leading to chronic fibrosis in …