Summary p27 Kip1 controls cell proliferation by binding to and regulating the activity of
cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and p27 stability are …

Cell cycle progression is regulated by cyclin-dependent kinases (cdk's), which in turn are
regulated by their interactions with stoichiometric inhibitors, such as p27Kip1. Although p27 …

The kinase inhibitor p27 Kip1 regulates the G 1 cell cycle phase. Here, we present data
indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of …

Whether p27 is a cyclin D-cdk4/6 inhibitor or not is controversial, and how it might switch
between these two modes is unknown. Arguing for a two-state mechanism, we show that …

p27Kip1 (p27), which controls eukaryotic cell division through interactions with cyclin-
dependent kinases (Cdks), integrates and transduces promitogenic signals from various …

Entry of cells into the cell division cycle requires the coordinated activation of cyclin‐
dependent kinases (cdks) and the deactivation of cyclin kinase inhibitors. Degradation of …

Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by
mental retardation, seizures, and tumors involving many organs, including the kidney, brain …

p27 mediates Cdk2 inhibition and is also found in cyclin D1-Cdk4 complexes. The present
data support a role for p27 in the assembly of D-type cyclin-Cdk complexes and indicate that …

The p27 Kip1 protein associates with G 1‐specific cyclin–CDK complexes and inhibits their
catalytic activity. p27 Kip1 is regulated at various levels, including translation, degradation …

Mitogenic signals stimulate cell division by activating cyclin/cyclin-dependent kinase (CDK)
complexes. Their timely regulation ensures proper cell cycle progression. It is therefore not …