Abstract Background/Aim: Painful vaso-occlusive crisis (VOC) is the most frequent
complication of sickle cell disease. The cause of VOC is believed to be ischemic tissue injury …

Background: Sickle cell disease (SCD) is a hereditary haemoglobinopathy characterized by
deranged haematopoiesis, and intermittent occlusion of small blood vessels. Patients can …

Sickle cell disease (SCD) is characterized by recurrent vaso-occlusive crisis (VOC). VOC is
an important index of disease severity and has been shown to correlate with the risk of multi …

Background: Sickle cell disease (SCA) was recognized as an inflammatory condition. C-
reactive protein (CRP) and white blood cell (WBC) count consider as biomarkers for …

Background: The platelet count, prothrombin time (PT), activated partial thromboplastin time
(APTT) and D-dimer levels of patients with sickle cell disease (SCD) in steady state (32 …

The aim of our study was to assess the cytokine profile of sickle cell disease (SCD) patients
in steady state and in vaso‐occlusive crisis (VOC). VOC has a complex nature, involving …

Background: Sickle cell anaemia (SCA) is a major cause of morbidity and mortality in Africa
where there is no readily available effective treatment. This study was designed to determine …

Background: Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as
well as in other haematological disorders. However, there is little information on the lipid …

Background: Sickle cell disease (SCD) is considered to be a hypercoagulable state that
contributes to the morbidity associated with the disease. Numerous mechanisms can …

Background: There is increasing evidence suggesting the contribution of platelets in the
vaso-occlusive phenomena found in sickle cell anaemia. This study is aimed at using …