Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor
P Zhao, T Guo, L Qian, X Wang, Y Yuan, Q Cheng… - Antiviral Research, 2017 - Elsevier
Abstract Type-I interferons (IFN-I) are important antiviral drugs which are widely used in
clinical therapy of diverse viral infections. However, understanding the detailed mechanisms …
clinical therapy of diverse viral infections. However, understanding the detailed mechanisms …
Small‐molecule inhibitors of ubiquitin‐specific protease 7 enhance type‐I interferon antiviral efficacy by destabilizing SOCS1
Y Yuan, Y Miao, C Zeng, J Liu, X Chen, L Qian… - …, 2020 - Wiley Online Library
Summary Type‐I interferons (IFN‐I) are used as common antiviral drugs for a range of viral
diseases in clinic. However, the antiviral efficacy of IFN‐I is largely restricted by negative …
diseases in clinic. However, the antiviral efficacy of IFN‐I is largely restricted by negative …
Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses
Q Liu, Y Wu, Y Qin, J Hu, W Xie, FXF Qin, J Cui - Science advances, 2018 - science.org
The innate immune response conferred by type I interferons is essential for host defense
against viral infection but needs to be tightly controlled to avoid immunopathology. We …
against viral infection but needs to be tightly controlled to avoid immunopathology. We …
An integrated view of deubiquitinating enzymes involved in type I interferon signaling, host defense and antiviral activities
G Qian, L Zhu, G Li, Y Liu, Z Zhang, J Pan… - Frontiers in …, 2021 - frontiersin.org
Viral infectious diseases pose a great challenge to human health around the world. Type I
interferons (IFN-Is) function as the first line of host defense and thus play critical roles during …
interferons (IFN-Is) function as the first line of host defense and thus play critical roles during …
HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response
L Zhang, F Huang, J Liu, Y Xu, Y Miao, Y Yuan… - Molecular …, 2021 - Elsevier
Abstract Type I interferon (IFN-I) plays pivotal roles in defense against viral infection. HSV-1
has evolved multiple strategies to evade IFN-I antiviral response. In this study, we revealed a …
has evolved multiple strategies to evade IFN-I antiviral response. In this study, we revealed a …
Deubiquitinase USP2a sustains interferons antiviral activity by restricting ubiquitination of activated STAT1 in the nucleus
STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation
is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1) …
is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1) …
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity
J Liu, L Jin, X Chen, Y Yuan, Y Zuo, Y Miao… - PLoS …, 2020 - journals.plos.org
CREB-binding protein (CBP) participates in numerous transcription events. However, cell-
intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts …
intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts …
c-Cbl-mediated ubiquitination of IRF3 negatively regulates IFN-β production and cellular antiviral response
X Zhao, H Zhu, J Yu, H Li, J Ge, W Chen - Cellular signalling, 2016 - Elsevier
Induction of type I interferon is a fundamental cellular response to viral infection. Interferon
regulatory factor 3 (IRF3) plays an essential role in Toll-like receptor (TLR) and retinoic acid …
regulatory factor 3 (IRF3) plays an essential role in Toll-like receptor (TLR) and retinoic acid …
Ubiquitin-conjugating enzyme 2S enhances viral replication by inhibiting type I IFN production through recruiting USP15 to deubiquitinate TBK1
L Huang, H Liu, K Zhang, Q Meng, L Hu, Y Zhang… - Cell reports, 2020 - cell.com
Type I interferon (IFN) plays an essential role in the host innate immune responses. Several
ubiquitin-conjugating enzyme (E2) family members were reported to regulate type I IFN …
ubiquitin-conjugating enzyme (E2) family members were reported to regulate type I IFN …
Ubiquitination network in the type I IFN‐induced antiviral signaling pathway
Q Zhao, R Zhang, C Qiao, Y Miao… - European Journal of …, 2023 - Wiley Online Library
Abstract Type I IFN (IFN‐I) is the body's first line of defense against pathogen infection. IFN‐I
can induce cellular antiviral responses and therefore plays a key role in driving antiviral …
can induce cellular antiviral responses and therefore plays a key role in driving antiviral …