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Transgenic mice (Cg-Tg (PDGFB-APPSwInd) 20Lms/2J) and their non-transgenic litter mate …

The use of lithium is well established in bipolar disorders and the benefits are being
demonstrated in neurodegenerative disorders. Recently, our group showed that treatment …

The glycogen synthase kinase-3β (GSK3β) pathway plays a central role in Alzheimer's
disease (AD) and its deregulation accounts for many of the pathological hallmarks of AD …

Lithium has been shown to delay the progression of Alzheimer's disease to reduce the
prevalence of dementia. However, its narrow therapeutic index and numerous toxic effects at …

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disorder with a
progressive loss of cognitive function. Currently, no effective treatment regimen is available …

It was already shown that microdoses of lithium carbonate (Li 2 CO 3) promoted memory
stabilization in humans and mice. Prolonged treatment also reduced neuronal loss and …

A lower incidence of dementia in bipolar patients treated with lithium has been described.
This metal inhibits the phosphorylation of glycogen-synthase-kinase 3-α and β, which are …

Telomere length (TL) is a biomarker of cell aging, and its shortening has been linked to
several age-related diseases. In Alzheimer's disease (AD), telomere shortening has been …

Recent electrophysiological work shows that chronic lithium treatment increases long-term
potentiation (LTP) in neurons of the hippocampus, and LTP is thought to be the major …

Background: Microdose lithium is protective against Alzheimer's disease (AD), although the
precise mechanisms through which its protective effects are conferred remain unclear …