Do nonsteroidal anti‐inflammatory drugs affect bone healing? A critical analysis

I Pountos, T Georgouli, GM Calori… - The Scientific World …, 2012 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) play an essential part in our approach to
control pain in the posttraumatic setting. Over the last decades, several studies suggested …

Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair

B Lisowska, D Kosson, K Domaracka - Drug design, development …, 2018 - Taylor & Francis
Tissue damage following injury triggers the processes of coagulation, inflammation and
healing. In tissues surrounding the bone, the result of the healing process is a scar, while …

The mechanisms of the inhibitory effects of nonsteroidal anti‐inflammatory drugs on bone healing: a concise review

AT Harder, YH An - The Journal of Clinical Pharmacology, 2003 - Wiley Online Library
Nonsteroidal anti‐inflammatory drug (NSAID) use continues to expand at a remarkable rate
due both to the broad spectrum of clinical applications for these medications and to the …

Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality

A Marquez-Lara, ID Hutchinson, F Nuñez Jr… - JBJS …, 2016 - journals.lww.com
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are often avoided by
orthopaedic surgeons because of their possible influence on bone-healing. This belief …

The effect of nonsteroidal anti-inflammatory drugs on bone healing in humans: a qualitative, systematic review

A Borgeat, C Ofner, A Saporito, M Farshad… - Journal of clinical …, 2018 - Elsevier
Study objective Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in
postoperative pain management. While an increasing number of in vitro and animal studies …

Effect of non-steroidal anti-inflammatory drugs on bone healing

J Cottrell, JP O'Connor - Pharmaceuticals, 2010 - mdpi.com
Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by
inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation …

[PDF][PDF] Do steroids, conventional non-steroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing

LA Boursinos, T Karachalios, L Poultsides… - J Musculoskelet …, 2009 - ismni.org
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs
worldwide. They are prescribed for orthopaedic conditions such as osteoarthritis, soft-tissue …

The effect of NSAIDs on spinal fusion: a cross-disciplinary review of biochemical, animal, and human studies

A Sivaganesan, S Chotai, G White-Dzuro… - European Spine …, 2017 - Springer
Purpose Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in
postoperative pain management. However, their use in the setting of spine fusion surgery …

Pharmacological agents and impairment of fracture healing: what is the evidence?

I Pountos, T Georgouli, TJ Blokhuis, HC Pape… - Injury, 2008 - Elsevier
Bone healing is an extremely complex process which depends on the coordinated action of
several cell lineages on a cascade of biological events, and has always been a major …

NSAID exposure and risk of nonunion: a meta-analysis of case–control and cohort studies

ER Dodwell, JG Latorre, E Parisini, E Zwettler… - Calcified tissue …, 2010 - Springer
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for postoperative pain
control. However, concerns regarding the potential deleterious effects of NSAIDs on bone …