A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats: role of lovastatin therapy

SE El-Swefy, ME Asker, SI Ali, HE Mohammed - Pharmacological research, 2002 - Elsevier
Estrogen replacement therapy (ERT) is claimed to reduce cardiovascular mortality by about
50% in postmenopausal women. This improvement is caused by favorable changes in lipid …

Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats

B Çetinkaya Demir, Y Uyar, K Özbilgin… - Journal of Obstetrics …, 2013 - Wiley Online Library
Aim: The goal of this study was to investigate the combined effects of raloxifene and
atorvastatin in aged ovariectomized rats during endothelial dysfunction and atherosclerotic …

Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups

K Moorthy, UCS Yadav, AK Mantha, SM Cowsik… - Biogerontology, 2004 - Springer
The effect of estradiol and progesterone therapy in serum and liver on the lipid profile of
naturally menopausal albino rats of the Wistar strain of different age groups (12, 18 and …

Protective effect of antioxidant adjuvant treatment with hormone replacement therapy against cardiovascular diseases in ovariectomized rats.

M Shehata, MA Kamel - Endocrine Regulations, 2008 - europepmc.org
Objective Since it is well known that estrogen deficiency or ovariectomy (OVX) results in a
reduction of sexual steroids and increased prevalence of cardiovascular diseases (CVD), it …

The anti-osteoporotic and anti-atherogenic effects of alendronate and simvastatin in ovariectomized rats fed high fat diet: a comparative study of combination therapy …

MT Mohamed, SA Abuelezz, SS Atalla… - Biomedicine & …, 2017 - Elsevier
Aim Epidemiological studies suggest a possible link between osteoporosis and
cardiovascular diseases. Mevalonate pathway was pointed to as a part of this link. This …

[HTML][HTML] Norgestimate and medroxyprogesterone acetate do not attenuate the atheroprotective effects of 17β-estradiol in ovariectomized, apolipoprotein E–deficient …

JM Shultz, XD Zhu, RH Knopp, RC LeBoeuf… - Fertility and sterility, 2004 - Elsevier
OBJECTIVE: To determine whether progestins counteract the cardioprotective effects of
estrogen. DESIGN: Controlled animal study. SETTING: Academic laboratory environment …

Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in …

HA Hassan, MA Abdel-Wahhab - Journal of physiology and biochemistry, 2012 - Springer
The aim of the present study was to investigate the cardiac biomarker changes in
experimental bilateral ovariectomized (OVX) rats in addition to evaluating the role of …

The effects of alone and combination tamoxifen, raloxifene and estrogen on lipid profile and atherogenic index of ovariectomized type 2 diabetic rats

MN Ebrahimi, M Khaksari, G Sepehri, GA Karam… - Life Sciences, 2020 - Elsevier
Introduction The cardiovascular dysfunctions in postmenopausal diabetic women increase
relative to premenopausal women. In this study we evaluated protective effects of selective …

Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels

SG Lundeen, JM Carver, ML McKean… - …, 1997 - academic.oup.com
Estrogens protect against cardiovascular disease in women through effects on the vascular
wall and liver. Here we further characterize the rat as a model for the evaluation of …

[HTML][HTML] Comparative effects of estrogen, raloxifene and tamoxifen on endothelial dysfunction, inflammatory markers and oxidative stress in ovariectomized rats

AZ Lamas, IF Caliman, PLM Dalpiaz, AF de Melo Jr… - Life sciences, 2015 - Elsevier
Aim Endothelial dysfunction is considered a premature indication of atherosclerosis and
vessel damage and is present in the postmenopausal period. This study compares the …