Primary sensory neurons with myelinated axons were examined in vitro in excised whole
lumbar dorsal root ganglia (DRGs) taken from adult rats up to 9 days after tight ligation and …

Whole cell patch-clamp recordings were obtained from dissociated mouse lumbar dorsal
root ganglion (DRG) neurons. Recordings were made from control neurons and neurons …

One of the physiological changes accompanying neuropathic pain from nerve injury is the
spontaneous firing of primary afferent fibers. At least some of this activity is thought to arise …

The spontaneous, ectopic activity in sensory nerves that is induced by peripheral nerve
injury is thought to contribute to the generation of “neuropathic” pain in humans. To examine …

Recent evidence indicates that neuropathic pain from partial peripheral nerve injury is
maintained by electrophysiologically abnormal signals from injured sensory neurons. To …

We examined the relation between ectopic afferent firing and tactile allodynia in the Chung
model of neuropathic pain. Transection of the L5 spinal nerve in rats triggered a sharp, four …

A number of good animal models have been developed in recent years that provide insights
into the mechanisms of neuropathic pain. It now becomes evident that there are two …

Abnormal afferent discharge originating at ectopic sites in injured primary sensory neurons
is thought to be an important generator of paraesthesias, dysaesthesias, and chronic …

Neuropathic pain in rodents can be driven by ectopic spontaneous activity (SA) generated
by sensory neurons in dorsal root ganglia (DRG). The recent demonstration that SA in …

A chronic compression of the dorsal root ganglion (CCD) produces ipsilateral cutaneous
hyperalgesia and allodynia in rats. Intracellular electrophysiological recordings from …