Transcending the skin barrier to deliver peptides and proteins using active technologies

N Singh, H Kalluri, A Herwadkar… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
Peptides and proteins have been investigated as promising therapeutic agents over the past
decade. These macromolecules are conventionally administered by the parenteral route …

Transdermal delivery of proteins

H Kalluri, AK Banga - Aaps Pharmscitech, 2011 - Springer
Transdermal delivery of peptides and proteins avoids the disadvantages associated with the
invasive parenteral route of administration and other alternative routes such as the …

Noninvasive transdermal delivery of peptides and proteins

O Pillai, V Nair, AK Jain, NS Thomas… - Drugs …, 2001 - access.portico.org
Revolutionary advances in biotechnology have given rise to a large number of drugs that
are of peptide and protein origin. In order to reap the ultimate therapeutic benefits of these …

Peptide and protein transdermal drug delivery

A Herwadkar, AK Banga - Drug Discovery Today: Technologies, 2012 - Elsevier
Peptides and proteins are gaining increasing importance as therapeutic agents. Oral
delivery of these molecules is not feasible due to gastrointestinal degradation. Parenteral …

Physical enhancement of transdermal drug application: is delivery technology keeping up with pharmaceutical development?

SE Cross, MS Roberts - Current drug delivery, 2004 - ingentaconnect.com
Advances in molecular biology have given us a wide range of protein and peptide-based
drugs that are unsuitable for oral delivery because of their high degree of first-pass …

Transdermal delivery of peptide and protein drugs: an overview

BG Amsden, MFA Goosen - AIChE journal, 1995 - Wiley Online Library
Recently, a large number of new and potentially potent peptide and protein drugs have been
developed. Their systemic delivery is difficult because they are rapidly cleared from the …

Emerging strategies for the transdermal delivery of peptide and protein drugs

YB Schuetz, A Naik, RH Guy… - Expert opinion on drug …, 2005 - Taylor & Francis
Transdermal delivery has been at the forefront of research addressing the development of
non-invasive methods for the systemic administration of peptide and protein therapeutics …

Proteins and peptides: strategies for delivery to and across the skin

HAE Benson, S Namjoshi - Journal of pharmaceutical sciences, 2008 - Elsevier
Despite the increased availability of therapeutic proteins and peptides, delivery remains
almost entirely via hypodermic needle. Transdermal delivery offers an attractive noninvasive …

Passive delivery of protein drugs through transdermal route

B Chaulagain, A Jain, A Tiwari, A Verma… - Artificial Cells …, 2018 - Taylor & Francis
Skin is the largest external organ in the human body but its use for therapeutic purposes has
been minimal. Stratum corneum residing on the uppermost layer of the skin provides a tough …

Recent advances in peptides for enhancing transdermal macromolecular drug delivery

R Ruan, M Chen, L Zou, P Wei, J Liu, W Ding… - Therapeutic …, 2016 - Taylor & Francis
Transdermal delivery of drugs, a compelling route of systemic drug delivery, provides
painless, reliable, targeted, efficient and cost effective therapeutic regimen for patients …