The vaso-occlusive crisis, or sickle cell crisis, is a common painful complication of sickle cell
disease in adolescents and adults. Acute episodes of severe pain (crises) are the primary …

For people with sickle cell disease, vaso-occlusive crisis pain is a frequently encountered
problem that poses unique and often perplexing challenges in management. This article …

The pain of vaso-occlusive crisis in sickle cell disease is excruciating and sometimes
incapacitating. 24, 34, 46 It is the most common and debilitating problem encountered by …

Acute vaso-occlusive crisis (VOC) is a hallmark of sickle cell disease (SCD). Multiple
complex pathophysiological processes can result in pain during a VOC. Despite significant …

Pain due to vaso-occlusive crisis is the major cause of hospital use in sickle cell disease.
Although available guidelines provide recommendations for opioid administration in this …

This narrative review aims to highlight the current paradigm on pain management in sickle
cell vaso-occlusive crisis. It specifically examines the pathophysiologic mechanisms of sickle …

Sickle cell disease results from an inherited defect of hemoglobin structure. It is the most
common serious genetic disorder found in blacks (1). In the United States alone, about 1500 …

Sickle-cell disease (SCD) is a wide-spread inherited hemolytic anemia that is due to a point
mutation, leading to the substitution of valine for glutamic acid, causing a spectrum of clinical …

Vaso-occlusive pain is a frequent manifestation of sickle cell disease, but most clinical
studies have documented only those pain episodes for which patients seek acute care or …

Early diagnosis, treatment, and prevention of a vaso‐occlusive crisis (VOC) are critical to the
management of patients with sickle cell disease. It is essential to differentiate between VOC …