Septins as diagnostic markers for a subset of human asthenozoospermia

Y Sugino, K Ichioka, T Soda, M Ihara… - The Journal of …, 2008 - auajournals.org
Purpose: Septins are the major constituents of the annulus, a submembranous ring that
separates the middle and principal pieces of spermatozoa. We previously reported its …

Relationship between absence of annulus and asthenozoospermia in Iranian men

H Hosseinifar, M Shafipour, T Modarresi… - Journal of assisted …, 2014 - Springer
Purpose To find a relationship between absence of annulus and asthenozoospermia in
Iranian men. Methods In the present study, semen samples from 100 asthenozoospermic …

The expression level of septin12 is critical for spermiogenesis

YH Lin, YM Lin, YY Wang, IS Yu, YW Lin… - The American journal of …, 2009 - Elsevier
Septins belong to a family of polymerizing GTP-binding proteins that are required for many
cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis …

Single‐nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility

A Rafaee, A Mohseni Meybodi… - Molecular …, 2020 - Wiley Online Library
SEPT12 is a testis‐specific gene involved in the terminal differentiation of male germ cells.
SEPT12 protein is required for sperm head‐tail formation and acts as a fundamental …

The expression pattern of SEPT7 correlates with sperm morphology

HCA Chao, YH Lin, YC Kuo, CJ Shen, HA Pan… - Journal of assisted …, 2010 - Springer
Purpose To investigate the expression pattern of the SEPT7 protein during spermatogenesis
and its potential role in sperm function. Methods We first investigated the expression pattern …

The role of the septin family in spermiogenesis

YH Lin, YC Kuo, HS Chiang, PL Kuo - Spermatogenesis, 2011 - Taylor & Francis
Septins (full name: Septin; symbol name: SEPT) belong to a family of polymerizing GTP
binding proteins that are required for many cellular functions, including membrane …

Biallelic loss‐of‐function mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in …

G Wang, X Zhu, Y Gao, M Lv, K Li, D Tang… - Human …, 2022 - Wiley Online Library
Asthenoteratozoospermia is the primary cause of infertility in humans. However, the genetic
etiology remains largely unknown for those suffering from severe asthenoteratozoospermia …

SEPT12 mutations cause male infertility with defective sperm annulus

YC Kuo, YH Lin, HI Chen, YY Wang, YW Chiou… - Human …, 2012 - Wiley Online Library
Septins are members of the GTPase superfamily, which has been implicated in diverse
cellular functions including cytokinesis and morphogenesis. Septin 12 (SEPT12) is a testis …

SEPTIN12 Genetic Variants Confer Susceptibility to Teratozoospermia

YH Lin, YY Wang, HI Chen, YC Kuo, YW Chiou… - PLoS …, 2012 - journals.plos.org
It is estimated that 10–15% of couples are infertile and male factors account for about half of
these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men …

Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa

M Ihara, A Kinoshita, S Yamada, H Tanaka… - Developmental cell, 2005 - cell.com
Septins are polymerizing GTP binding proteins required for cortical organization during
cytokinesis and other cellular processes. A mammalian septin gene Sept4 is expressed …