Amyloid precursor protein (APP), associated with Alzheimer's disease plaques, is known to
be present in synapses of the brain and in the adult neuromuscular junction (NMJ). In the …

Compelling evidence from in vivo model systems within the past decade shows that the APP
family of proteins is important for synaptic development and function in the central and …

A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD)
pathogenesis has been well established. However, the physiological function of APP …

Biochemical and genetic studies place the amyloid precursor protein (APP) at the center
stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead …

Although abnormal processing of β-amyloid precursor protein (APP) has been implicated in
the pathogenic cascade leading to Alzheimer's disease, the normal function of this protein is …

At the postsynaptic domain of the human neuromuscular junction (NMJ), we have
demonstrated strong concentrations of the N-terminus 45–62, C-terminus 676–695 and β …

Kunitz‐inhibitor containing forms of the β‐amyloid precursor protein (βAPP), known also as
protease nexin II (PNII), and α1‐antichymotrypsin (α1‐ACT), a serpin, are important …

Metabolism of the amyloid precursor protein (APP) may contribute to the molecular changes
observed in Alzheimer's disease, but the function of the protein in the non-pathologic …

Regenerating muscle fibers in 25 human muscle biopsies, obtained from patients with a
variety of neuromuscular diseases, manifested increased mRNA for the β-amyloid precursor …

Alzheimer's amyloid precursor protein (APP), the precursor of β-amyloid (Aβ), is an integral
membrane protein with a receptor-like structure. We recently demonstrated that the mature …