Disturbed homocysteine metabolism is a risk factor for Alzheimer's disease (AD) and may
contribute to the disease pathophysiology by increasing both amyloid-β (Aβ) production and …

Background: Increased plasma homocysteine levels have been described as an
independent risk factor for Alzheimer's disease (AD), but the underlying pathophysiology is …

Background: Increased plasma total homocysteine (tHcy) is a risk factor for neurological
diseases, but the underlying pathophysiology has not been adequately explained. Methods …

Dimethylarginine and homocysteine metabolism are closely linked and alterations of both
were observed in plasma and cerebrospinal fluid (CSF) of patients with Alzheimer's disease …

Background Elevated plasma homocysteine and amyloid β (Aβ) have been associated with
Alzheimer's disease (AD). We investigated the cross-sectional association between these …

Disturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the
amyloid precursor protein (APP) production and processing. The objective of this study was …

Objective Hyperhomocysteinemia (HHcy), as an important risk factor for Alzheimer's disease
(AD), would aggravate cognitive dysfunction. This study aimed to investigate whether and to …

Background: Serum homocysteine (Hcy) level is considered to be an important biomarker for
Alzheimer's disease (AD); however, the status of Hcy in brain tissue, and the association …

Dementia is a common and devastating public health problem, affecting an estimated
5±10% of individuals over the age of 65 [1]. Two pathologically distinct subtypes of …

Objective: To explore the association between high homocysteine levels and risk of
Alzheimer disease (AD) in the Washington Heights-Inwood Columbia Aging Project …