Wiskott-Aldrich Syndrome protein (WASp) and related proteins stimulate actin filament
nucleation by Arp2/3 complex. The isolated C-terminal VCA domain of WASp …

Actin polymerization at the cell cortex is thought to provide the driving force for aspects of
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …

Wiskott-Aldrich syndrome protein (WASP) and neural (N)-WASP regulate dynamic actin
structures through the ability of their VCA domains to bind to and stimulate the actin …

Neural Wiskott-Aldrich syndrome protein (N-WASP) is an essential regulator of actin
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It …

Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …

The 70 C-terminal amino acids of Wiskott-Aldrich syndrome protein (WASp WA) activate the
actin nucleation activity of the Arp2/3 complex. WASp WA binds both the Arp2/3 complex …

Wiskott-Aldrich syndrome proteins (WASP) are a family of proteins that all catalyze actin
filament branching with the Arp2/3 complex in a variety of actin-based motile processes. The …

We purified native WASp (Wiskott-Aldrich Syndrome protein) from bovine thymus and
studied its ability to stimulate actin nucleation by Arp2/3 complex. WASp alone is inactive in …

Wiskott–Aldrich syndrome protein (WASP)-homology domain 2 (WH2) is a small and
widespread actin-binding motif. In the WASP family, WH2 plays a role in filament nucleation …

In response to signaling, the Arp2/3 complex (actin-related proteins 2 and 3 complex) is
activated by binding the C-terminal (WA) domain of proteins of the Wiskott-Aldrich Syndrome …