[HTML][HTML] Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss
M Mavrikaki, C Girardet, A Kern, AF Brantley… - Molecular …, 2016 - Elsevier
Objective Appetitive responses to weight loss are mediated by a nutrient-sensing neural
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors …
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors …
Melanocortin‐3 receptors are involved in adaptation to restricted feeding
K Begriche, OJ Marston, J Rossi… - Genes, Brain and …, 2012 - Wiley Online Library
The central nervous melanocortin system forms a neural network that maintains energy
homeostasis. Actions involving neural melanocortin‐3 receptors (MC3Rs) regulate the …
homeostasis. Actions involving neural melanocortin‐3 receptors (MC3Rs) regulate the …
[HTML][HTML] A life without hunger: the ups (and downs) to modulating melanocortin-3 receptor signaling
AA Butler, C Girardet, M Mavrikaki… - Frontiers in …, 2017 - frontiersin.org
Melanocortin neurons conserve body mass in hyper-or hypo-caloric conditions by conveying
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …
signals from nutrient sensors into areas of the brain governing appetite and metabolism. In …
[HTML][HTML] Divergence of melanocortin pathways in the control of food intake and energy expenditure
N Balthasar, LT Dalgaard, CE Lee, J Yu, H Funahashi… - Cell, 2005 - cell.com
Summary Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by
decreasing food intake and increasing energy expenditure. MC4Rs are expressed in …
decreasing food intake and increasing energy expenditure. MC4Rs are expressed in …
[HTML][HTML] Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and …
K Begriche, PR Levasseur, J Zhang, J Rossi… - Journal of Biological …, 2011 - ASBMB
The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition,
natriuresis, immune function, and entrainment of circadian rhythms to nutrient intake. MC3Rs …
natriuresis, immune function, and entrainment of circadian rhythms to nutrient intake. MC3Rs …
[HTML][HTML] Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice
Abstract Background Melanocortin 4 receptor (MC4R) activity in the hypothalamus is crucial
for regulation of metabolism and food intake. The peptide ligands for the MC4R are …
for regulation of metabolism and food intake. The peptide ligands for the MC4R are …
[HTML][HTML] Melanocortin-3 receptors expressed in Nkx2. 1 (+ ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning
C Girardet, MM Mavrikaki, JR Stevens, CA Miller… - Scientific Reports, 2017 - nature.com
Abstract Melanocortin-3 receptors (MC3R) have a contextual role in appetite control that is
amplified with hypocaloric conditioning. C57BL/6J (B6) mice subjected to hypocaloric …
amplified with hypocaloric conditioning. C57BL/6J (B6) mice subjected to hypocaloric …
[HTML][HTML] Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
AA Van Der Klaauw, JM Keogh, E Henning… - Nature …, 2016 - nature.com
Abstract Melanocortin-4-receptor (MC4R)-expressing neurons modulate food intake and
preference in rodents but their role in human food preference is unknown. Here we show …
preference in rodents but their role in human food preference is unknown. Here we show …
[HTML][HTML] Melanocortin 3 receptor signaling in midbrain dopamine neurons increases the motivation for food reward
R Pandit, A Omrani, M Luijendijk… - …, 2016 - nature.com
The central melanocortin (MC) system mediates its effects on food intake via MC3 (MC3R)
and MC4 receptors (MC4R). Although the role of MC4R in meal size determination …
and MC4 receptors (MC4R). Although the role of MC4R in meal size determination …
Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning
H Cui, BL Mason, C Lee, A Nishi, JK Elmquist… - Physiology & …, 2012 - Elsevier
It is now widely recognized that exposure to palatable foods engages reward circuits that
promote over-eating and facilitate the development of obesity. While the melanocortin 4 …
promote over-eating and facilitate the development of obesity. While the melanocortin 4 …