Integration of the retrovirus DNA genome into host chromosomes is essential for viral
replication. After virus infection of the cell, synthesis of viral cDNA occurs by reverse …

The single-stranded genomic RNA of retroviruses is reverse-transcribed to produce double-
stranded linear DNA shortly after entry of the virion into the host cell. For HIV, this reaction …

Retroviral DNA integration involves a coordinated set of DNA cutting and joining reactions.
We find that the IN protein of Moloney murine leukemia virus (MoMLV) is the only viral …

Retroviruses such as human immunodeficiency virus (HIV) are distinguished from other
viruses by the combination of two steps in the viral life cycle. The first is reverse transcription …

The completion of the human genome sequence has made possible genome-wide studies
of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences …

One of the most crucial steps in the life cycle of a retrovirus is the integration of the viral DNA
(vDNA) copy of the RNA genome into the genome of an infected host cell. Integration …

Retroviruses differ in their preferences for sites for viral DNA integration in the chromosomes
of infected cells. Human immunodeficiency virus (HIV) integrates preferentially within active …

The integration of retroviral DNA appears to be obligatory for the efficient replication of
retroviruses in their respective host cells. During a natural infection, integration takes place …

To investigate retroviral integration targeting on a nucleotide scale, we examined the base
frequencies directly surrounding cloned in vivo HIV-1, murine leukemia virus, and avian …

Retroviruses integrate a DNA copy of the viral genome into cellular DNA as an obligatory
step in the viral replication cycle. Once integrated, the viral DNA is stably replicated with …