An asymmetric Mannich reaction of phenylacetate thioesters and sulfonylimines using
cinchona alkaloid-based amino (thio) urea catalysts is reported that employs proximity …

An efficient urea-enhanced thiourea catalyst enables the enantioselective Mannich reaction
between β-keto esters and N-Boc-protected imines under mild conditions and minimal …

We describe the first efficient, direct asymmetric Mannich reactions with malonates and N-
Boc aryl and alkyl imines by cooperative hydrogen-bonding catalysis with a cinchona …

Insights into the role played by modified cinchona alkaloids in the Sharpless asymmetric
dihydroxylation inspired studies of modified cinchona alkaloids as chiral organic catalysts …

We report a scalable, one-pot Mannich route to enantioenriched α-amino esters by direct
reaction of α-chloroglycine ester as a practical imino ester surrogate. The reaction is …

Wynberg's report from 1977 that natural cinchona alkaloids catalyze the asymmetric
conjugate addition of aromatic thiols to cycloalkenones is a landmark discovery in hydrogen …

An asymmetric Mannich reaction has been developed to generate chiral β-amino esters in
good yields with excellent enantiomeric excesses (ee, up to 99%) using a chiral bifunctional …

We describe a biomimetic organocatalytic enantioselective decarboxylative addition of
malonic acid half thioesters to imines. This simple protocol makes use of readily available …

β-Amino-α-ketoacids are important unnatural amino acids that exhibit unique bioactivity and
reactivity derived from the highly electrophilic carbonyl group at the α-position. Despite the …

An organocatalytic asymmetric Mannich reaction of allylic ketones with cyclic N-sulfonyl α-
iminoester has been developed. By using a saccharide-derived chiral tertiary amino …