Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

Foxp3 has been shown to be both necessary and sufficient for the development and function
of naturally arising CD4+ CD25+ regulatory T cells in mice. Mutation of Foxp3 in Scurfy mice …

Regulatory T cells are capable of suppressing deleterious immune responses against self-or
non-self-antigens. Their essential role in tolerance and immune regulation has been …

Regulatory T (TReg) cells constitute a unique T-cell lineage that has a crucial role in
immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the …

Regulatory T cells (Treg cells), whose differentiation and function are controlled by
transcription factor Foxp3, express the closely related family member Foxp1. Here we …

The forkhead family transcription factor FOXP3 has been shown to be critical for the
development and function of CD4+ CD25+ regulatory T cells. Recently, FOXP3 expression …

Abstract CD4+ CD25+ regulatory T cells are essential for the active suppression of
autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically …

Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is,
understandably, a highly controlled process and one which many investigators want to …

Abstract Forkhead box P3 (Foxp3) is an important transcription factor that belongs to the
forkhead/winged-helix family of transcriptional regulators. Foxp3 has been extensively …