BACKGROUND Chemotherapy and radiation treatments for cancer and other diseases can
cause male infertility. There are currently no options to preserve the fertility of prepubertal …

BACKGROUND Approximately 80% of childhood cancers can now be cured but a side effect
of treatment results in about one-third of the surviving boys being infertile or severely …

The current strategy to preserve fertility of male prepubertal cancer patients consists of
cryopreservation of a testicular tissue biopsy containing spermatogonial stem cells (SSCs) …

Spermatogonial stem cell (SSC) culture and transplantation pave the way for clinical
restoration of fertility in male prepubertal cancer survivors. In this chapter we detail the steps …

Current cancer treatment regimens do not only target tumor cells, but can also have
devastating effects on the spermatogonial stem cell pool, resulting in a lack of functional …

Advancements in cancer therapies over the past several decades have led to a rise in
pediatric cancer survival rates to approximately 88%. 1 This increase in cancer survivorship …

Spermatogonial stem cells open novel strategies for preservation of testicular tissue and
fertility preservation in boys and men exposed to gonadotoxic therapies. This review …

Context Young boys treated with high-dose chemotherapy are often confronted with infertility
once they reach adulthood. Cryopreserving testicular tissue before chemotherapy and …

Spermatogonial stem cell (SSC) transplantation has been shown to restore fertility in several
species and may have application for treating some cases of male infertility (eg, secondary …

Cryopreservation of testicular tissue before cancer therapy for fertility preservation in
prepubertal boys with cancer is of great interest in reproductive medicine. Isolation of …