Amiodarone therapy leads to a significant impairment in myocardial conduction, yet it
causes only a modest decrease in the maximum rate of depolarization of the action potential …

The electrophysiologic effects of amiodarone were examined in 13 dogs that received 30 g
amiodarone orally during 3 weeks and compared with 13 control dogs that did not receive …

Isolated tissue experiments (canine ventricular epicardium) and computer simulations were
used to characterize the relationship between changes in maximum rate of depolarization …

The effects of 30 min zero-flow ischaemia and reperfusion on the electrophysiological
properties of amiodarone were studied in 11 rabbits treated with oral amiodarone (mean …

We have investigated the relationship between the myocardial disposition kinetics of
amiodarone and the time course of its electrophysiologic effects in an open-chested …

The electrophysiologic effects of incremental doses of intravenous amiodarone were studied
in the intact neonatal canine heart and were compared with the responses observed in the …

To study the electrophysiologic effects of chronically administered amiodarone and its
interaction with an I (Kr) blocker, amiodarone was injected ip daily for 7 days into male …

This article reviews experimental studies on the electrophysiological effects of amiodarone
on mammalian hearts. Acute application of amiodarone (0.1-10ƒÊM) to papillary muscles or …

We examined the temporal kinetics of onset and offset of the cardiac electrophysiologic
effects of orally administered amiodarone in chronically instrumented, unsedated adult dogs …

The acute and chronic effects of amiodarone were studied on the transmembrane ionic
currents in rabbit single ventricular myocytes at 35 degrees C by applying the whole-cell …