Lipid identification and quantification are essential objectives in comprehensive lipidomics
studies challenged by the high number of lipids, their chemical diversity, and their dynamic …

Detailed analysis of lipid species can be challenging due to their structural diversity and
wide concentration range in cells, tissues, and biofluids. To address these analytical …

Quantification is an essential task in comprehensive lipidomics studies challenged by the
high number of lipids, their chemical diversity and their dynamic range of the lipidome. In this …

Conspectus Lipids play critical structural and functional roles in the regulation of cellular
homeostasis, and it is increasingly recognized that the disruption of lipid metabolism or …

The goal of untargeted lipidomics is to have high throughput, yet comprehensive and
unambiguous identification and quantification of lipids. Novel stationary phases in LC …

Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS)-based
methods have become the gold standard methodology for the comprehensive profiling of the …

Lipids, serving as the structural components of cellular membranes, energy storage, and
signaling molecules, play the essential and multiple roles in biological functions of …

Recent advances in mass spectrometry have expanded our knowledge of lipids and lipid
metabolic pathways involved in many (patho) physiological events. Targeted and non …

Shotgun lipidomics is a powerful tool that enables simultaneous and fast quantification of
diverse lipid classes through mass spectrometry based analyses of directly infused crude …

Natural lipidomes are characterized by extremely high complexity and dynamic range of
lipid concentrations. Furthermore, high diversity of lipid physicochemical properties requires …