Roughly 10% of eukaryotic transmembrane proteins are found on the nuclear membrane,
yet how such proteins target and translocate to the nucleus remains in dispute. Most models …

To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear
pore complex or it must be small enough to pass through by diffusion. Although these …

Active nuclear import of soluble cargo involves transport factors that shuttle cargo through
the nuclear pore complex (NPC) by binding to phenylalanine-glycine (FG) domains. How …

The inner nuclear membrane harbors a unique set of membrane proteins, many of which
interact with nuclear intermediate filaments and chromatin components and thus play an …

The mechanism for nucleo-cytoplasmic transport of integral membrane proteins is poorly
understood compared to transport of soluble molecules. We recently demonstrated that at …

For a eukaryotic cell to function, its genome has to communicate with its cytoplasm. The
genome however is surrounded by a double membrane which is impermeable to the …

The nuclear envelope contains> 100 transmembrane proteins that continuously exchange
with the endoplasmic reticulum and move within the nuclear membranes. To better …

The nuclear pore complex (NPC), the sole gateway for nucleocytoplasmic exchange in
eukaryotic cells, allows for the passive diffusion of small molecules and transport-receptor …

Nuclear pore complexes (NPCs) act as effective and robust gateways to the nucleus,
allowing only the passage of selected macromolecules across the nuclear envelope. NPCs …

Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …